Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats

Table 1 Effect of 6-paradol on colon GSH, Serum GSH and Serum TNF-α, in acetic acid-induced colitis rats

Parameter	Group [Mean ± SEM (95%CI)]						F	p	Partial Eta Squared (η²_p)
Parameter	NC	AC	SG	LT	MT	HT	F	p	Partial Eta Squared (η²_p)
Colon GSH^a,b (mmol/mg)	6.71 ± 0.32 (5.95, 7.47)	1.92 ± 0.08 (1.73, 2.11)	6.23 ± 0.15 (5.86, 6.61)	3.82 ± 0.13 (3.51, 4.13)	4.47 ± 0.17 (4.06, 4.88)	6.45 ± 0.25 (5.84, 7.05)	85.27	0.001	0.900
Serum GSH^a,c (μmol/l)	12.82 ± 0.54 (11.54, 14.10)	4.10 ± 0.10 (3.85, 4.34)	11.20 ± 0.37 (10.32, 12.07)	5.96 ± 0.18 (5.52, 6.40)	8.73 ± 0.33 (7.94, 9.52)	10.97 ± 0.20 (10.49, 11.45)	108.35	0.001	0.919
Serum TNF-α^a,b (pg/ml)	18.41 ± 0.09 (16.27, 20.55)	51.25 ± 1.50 (47.68, 54.81)	19.11 ± 0.84 (17.10, 21.12)	41.53 ± 2.26 (36.19, 46.88)	30.05 ± 0.51 (28.82, 31.27)	22.62 ± 0.55 (21.31, 23.93)	112.38	0.001	0.922

Legend: Effects of 6-paradol at different doses on colon GSH, serum GSH and serum TNF-α in acetic acid-induced colitis rats, analysed by one-way ANOVA followed by a posthoc Tukey’s test for pairwise comparison; ^asignificant difference with AC (All parameters); ^bsignificant difference with NC (for colonic GSH, and Serum TNF-α); ^csignificant difference with NC (for serum GSH); Effect size (η2p); NC Normal control, AC Acetic acid-induced colitis untreated, SG Sulfasalazine treated (500 mg/kg), LT Low-dose 6-paradol (50 mg/kg), MT Medium-dose 6-paradol (100 mg/kg), HT High-dose 6-paradol (200 mg/kg); GSH Glutathione, TNF Tumour necrosis factor

ISSN: 2662-7671