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Fig. 3 | BMC Complementary Medicine and Therapies

Fig. 3

From: Dasatinib reverses drug resistance by downregulating MDR1 and Survivin in Burkitt lymphoma cells

Fig. 3

Effects of MDR1 and Survivin inhibitors on HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cell drug sensitivity. a HS-Sultan, HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells were incubated with the represented concentrations of adriamycin, vincristine, dexamethasone, melphalan, and verapamil for 72 h. Detection of dead cells number was performed by trypan blue staining. Results are notable example of five independent experiments. *p < 0.01 vs. control (ANOVA with Dunnett’s test). b mRNA expression of Survivin analyzed by real-time PCR. The results were normalized to GAPDH mRNA levels and are notable example of five independent experiments. *p < 0.01 vs. control (ANOVA with Dunnett’s test). c HS-Sultan, HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells were incubated with the represented concentrations of adriamycin, vincristine, dexamethasone, melphalan, and Survivin siRNA for 72 h. Detection of dead cells number was performed by trypan blue staining. Results are notable example of five independent experiments. *p < 0.01 vs. control cells (ANOVA with Dunnett’s test)

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