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Table 5 Fractional inhibitory concentration (FIC) and FIC indices (FICI) of ITC-hydrolate of C. capitatus pairs against Candida strains

From: Evaluation of antimicrobial activity of the hydrolate of Coridothymus capitatus (L.) Reichenb. fil. (Lamiaceae) alone and in combination with antimicrobial agents

Yeasts   MICa MICc FIC FICI Type of interaction
C. krusei 398 Itraconazole 2 0.25 0.125 0.375 Synergy
Hydrolate 25 (0.035)a 6.25 (0.009)a 0.25   
C. albicans 183 Itraconazole 0.5 0.06 0.12 0.62 Additive
Hydrolate 50 (0.070) 25 (0.035) 0.5   
C. albicans ATCC 90028 Itraconazole 0.5 0.125 0.5 1 Additive
Hydrolate 50 (0.070) 25 (0.035) 0.5   
C. albicans ATCC 10231 Itraconazole 1 1 1 2 Indifference
Hydrolate 50 (0.070) 50 (0.070) 1   
C. glabrata 32–09 Itraconazole 1 1 1 2 Indifference
Hydrolate 6.25 (0.009) 6.25 (0.009) 1   
  1. (As essential oil % (v/v) content in hydrolate product)a
  2. MICa, MIC of one sample alone; MICc, MIC of one sample of the most effective combination
  3. FIC of itraconazole = MIC of itraconazole in combination with hydrolate/MIC of itraconazole alone
  4. FIC of hydrolate = MIC of hydrolate in combination with itraconazole/MIC of hydrolate alone
  5. FICI = FIC of itraconazole+FIC of hydrolate
  6. FICI ≤0.5, synergy; FICI > 0.5 and ≤ 1, additive; FICI > 1 and ≤ 4, indifference; FICI > 4 antagonism