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Table 5 Fractional inhibitory concentration (FIC) and FIC indices (FICI) of ITC-hydrolate of C. capitatus pairs against Candida strains

From: Evaluation of antimicrobial activity of the hydrolate of Coridothymus capitatus (L.) Reichenb. fil. (Lamiaceae) alone and in combination with antimicrobial agents

Yeasts MICaMICcFICFICIType of interaction
C. krusei 398Itraconazole20.250.1250.375Synergy
Hydrolate25 (0.035)a6.25 (0.009)a0.25  
C. albicans 183Itraconazole0.
Hydrolate50 (0.070)25 (0.035)0.5  
C. albicans ATCC 90028Itraconazole0.50.1250.51Additive
Hydrolate50 (0.070)25 (0.035)0.5  
C. albicans ATCC 10231Itraconazole1112Indifference
Hydrolate50 (0.070)50 (0.070)1  
C. glabrata 32–09Itraconazole1112Indifference
Hydrolate6.25 (0.009)6.25 (0.009)1  
  1. (As essential oil % (v/v) content in hydrolate product)a
  2. MICa, MIC of one sample alone; MICc, MIC of one sample of the most effective combination
  3. FIC of itraconazole = MIC of itraconazole in combination with hydrolate/MIC of itraconazole alone
  4. FIC of hydrolate = MIC of hydrolate in combination with itraconazole/MIC of hydrolate alone
  5. FICI = FIC of itraconazole+FIC of hydrolate
  6. FICI ≤0.5, synergy; FICI > 0.5 and ≤ 1, additive; FICI > 1 and ≤ 4, indifference; FICI > 4 antagonism