Bacteria | Combination | MICa | MICc | FIC | FICI | Type of interaction |
---|
S. aureus ATCC 43300 | Tetracycline | 0.125 | 0.125 | 1 | 1.48 | Indifference |
Hydrolate | 25 (0.035)a | 12.5 (0.017)a | 0.48 | Â | Â |
S. aureus 815 (MRSA) | Tetracycline | 0.25 | 0.125 | 0.5 | 0.98 | Additive |
Hydrolate | 25 (0.035) | 12.5 (0.017) | 0.48 | Â | Â |
S. aureus 74CCH (MRSA) | Tetracycline | 0.25 | 0.125 | 0.5 | 0.98 | Additive |
Hydrolate | 25 (0.035) | 12.5 (0.017) | 0.48 | Â | Â |
- (As essential oil % (v/v) content in hydrolate product)a
- MICa, MIC of one sample alone; MICc, MIC of one sample of the most effective combination
- FIC of antibiotic = MIC of antibiotic in combination with hydrolate/MIC of antibiotic alone
- FIC of hydrolate = MIC of hydrolate in combination with antibiotic/MIC of hydrolate alone
- FICI = FIC of antibiotic+FIC of hydrolate
- FICI ≤0.5, synergy; FICI > 0.5 and ≤ 1, additive; FICI > 1 and ≤ 4, indifference; FICI > 4 antagonism