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Table 7 Blood pressure, renal functions, and liver functions in safety issue

From: Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial

DataaTreatmentWeek 0Week 3Week 6p-value**
Blood pressure
 Systolic blood pressureGinger extract117.05 (9.60)113.76 (9.73)111.54 (17.91)0.767
 (Normal ≤140 mm.Hg.)Loratadine115.28 (13.16)114.37 (12.44)114.25 (14.86)
 Diastolic blood pressureGinger extract75.95 (9.48)73.73 (9.99)74.58 (12.65)0.112
 (Normal ≤90 mm.Hg.)Loratadine72.10 (10.15)70.08 (11.74)71.19 (11.88)
Renal functions    0.729
 Blood urea nitrogen; BUN (mg/dL)Ginger extract11.81(3.47)11.26 (2.48)10.77 (3.32)
 (ref. range = 7.0–18.0)Loratadine11.50 (3.59)11.32 (2.71)10.61 (2.26)
 Creatinine (mg/dL)Ginger extract0.74 (0.18)0.76 (0.19)0.74 (0.23)0.826
 (ref. range = 0.7–1.3)Loratadine0.74 (0.18)0.75 (0.18)0.75 (0.16)
Liver functions
 AST (U/L) (ref. range = 15–37)Ginger extract21.13 (6.71)19.81 (5.18)20.19 (6.92)0.871
 Loratadine20.85 (8.73)24.38 (14.66)20.56 (5.95)
 ALT (U/L) (ref. range = 30–65)Ginger extract28.38 (11.96)27.51 (12.92)26.78 (11.39)0.586
 Loratadine27.05 (13.35)29.51 (20.52)27.08 (12.28)
 ALP (U/L) (ref. range = 46–116)Ginger extract60.93 (13.68)62.30 (16.73)58.11(17.66)0.118
 Loratadine65.88 (21.93)67.89 (25.00)68.72 (25.04)
  1. aData represent mean (SD), **Statistical analysis: repeated measured ANOVA, †Significant difference from day 0 within group (p < 0.05), ††significant difference from day 0 within group (p < 0.01), and†††significant difference from day 0 within group (p < 0.001)