RETRACTED ARTICLE: Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression

Table 4 Effect of quercetin, kaempferide, and isorhamnetin on cell proliferation inhibition rate in rat hepatocyte–KCs. The hepatocyte–KCs were respectively incubated at various concentrations of quercetin, kaempferide, and isorhamnetin (25, 50, and 100 μg/ml) and LPS (1 mg/l) for 24 H. IL-6 and TNF-α in the hepatocyte–KCs were measured using ELISA, and cells proliferation inhibition rate was measured using MTT. #P < 0.05: compared with the control group; *P < 0.05: compared with the LPS group

Drug	LPS (1 mg/l)	Dose (μg/ml)	Proliferation inhibition rate (%)	IL-6 (pg/ml)	TNF-α (pg/ml)
Control	–	0	47.4 ± 10.4	0.43 ± 0.17	0.35 ± 0.11
Model	+	0	16.3 ± 4.6^#	1.59 ± 0.64^#	1.37 ± 0.37^#
Quercetin	+	25	28.6 ± 5.3*	0.98 ± 0.42*	0.84 ± 0.38*
	+	50	34.2 ± 7.1*	0.65 ± 0.29*	0.63 ± 0.19*
	+	100	43.8 ± 9.7*	0.49 ± 0.18*	0.48 ± 0.14*
kaempferide	+	25	19.7 ± 7.9	1.33 ± 0.47	1.28 ± 0.41
	+	50	31.1 ± 6.8*	0.85 ± 0.36*	0.89 ± 0.34*
	+	100	39.9 ± 11.7*	0.61 ± 0.19*	0.67 ± 0.22*
Isorhamnetin	+	25	18.5 ± 8.2	1.37 ± 0.44	1.23 ± 0.47
	+	50	31.9 ± 9.8*	0.89 ± 0.25*	0.92 ± 0.33*
	+	100	40.4 ± 11.3*	0.64 ± 0.18*	0.71 ± 0.29*

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