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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: RETRACTED ARTICLE: Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression

Fig. 4

SHH is a miR-124 target. a SHH mRNA levels decreased in miR-124-overexpressing rat hepatocyte–KCs (P < 0.05). b Overexpressing miR-124 in rat hepatocyte–KCs decreased SHH protein levels compared with that of vector controls (P < 0.05). c MiR-124 bound to SHH-3′UTR-wt, but the binding was blocked by SHH-3′UTR-mt. d Dual-luciferase reporter assays confirmed that miR-124 mimic bound to SHH-3′UTR-wt but not the mutated form (P < 0.05)

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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