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Fig. 2 | BMC Complementary Medicine and Therapies

Fig. 2

From: RETRACTED ARTICLE: Sedum sarmentosum Bunge extract ameliorates lipopolysaccharide- and D-galactosamine-induced acute liver injury by attenuating the hedgehog signaling pathway via regulation of miR-124 expression

Fig. 2

Effect of miR-124 on the Hedgehog signaling pathway, inflammatory response, and cell proliferation inhibition rate in rat hepatocyte–KCs. (a and b) qRT-PCR analysis of miR-124 levels in rat hepatocyte–KCs transfected with control mimic, miR-124 mimic, control inhibitor, or miR-124 inhibitor for 24 h. (c and d) Quantitative Western blot analysis of Hedgehog, Ptch, Smo, Gli, Akt, p-IkB-а, and NF-kB65 protein levels in rat hepatocyte–KCs transfected with control mimic, miR-124 mimic, control inhibitor, or miR-124 inhibitor for 24 h. (e and f) Levels of IL-6 and TNF-а in rat hepatocyte–KCs with control mimic, miR-124 mimic, control inhibitor, or miR-124 inhibitor for 24 h. Data are expressed as mean ± SD of three independent experiments. *P < 0.05: versus control mimic; #P < 0.05: versus control inhibitor

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