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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells

Fig. 6

The molecular mechanism of germacrone blocked OGD/R-induced autophagy in PC12 cells (A) Compare the effect of treatment with PI3K III inhibitor (3-MA)(a) and PI3K I inhibitor (ZSTK474)(b). Detection of the protein expression of LC3, Beclin-1, PI3K III, Bcl-2, PI3K I, p-Akt and p-mTOR in PC12 cells by Western Blot. (B-H) Quantitative analysis of the gray value of each protein band. Note: n = 3; ##P < 0.01, vs control group; *P < 0.05, **P < 0.01, vs OGD/R group. p-Class I PI3K: PI3K I protein; p-Akt: Akt protein; p-mTOR: mTOR protein; Class III PI3K: PI3K III protein

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