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Table 1 The small compounds from Chinese herbal medicines and their effect on fibril formation, oligomerization and toxicity

From: Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

ID

Name

Inhibition of fibril formation (Th-T)a

Inhibition of fibril formation (CR)b

Inhibition of seeded fibril formationc

Inhibition of neurotoxicityd

CMC 1

Salvianolic acid B

+ + +

+++

+ + +

+ + +

CMC2

Ammonium Glycyrrhizinate

+

+

–

–

CMC3

Puerarin

–

–

–

–

CMC4

Sinomenine

+

–

–

+

CMC5

Paeoniflorin

+

–

–

–

CMC6

Gamma-Schisandrin

–

 

–

–

CMC7

Dihydromyricetin

+ + +

+++

+ + +

+ + +

CMC8

Magnolol

–

–

–

–

CMC9

Honokiol

+

–

–

+

CMC10

Geniposide

–

–

–

–

CMC11

Bilobalide

++

+

–

+

  1. aInhibition of α-syn fibril formation was tested by Th-T assay. bInhibition of α-syn fibril formation was tested by Congo red assay. cInhibition of α-syn seeded fibril formation was tested by seeding assay. dInhibition of α-syn fibril toxicity toward M17-neuroblastoma cells was tested by MTT assay. (+ + +, very potent; ++, potent; +, moderate; −, no effect)