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Table 1 IC50 and selective index values of methanolic Viola tricolor and acetonic Laurus nobilis extracts

From: Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Crude extractBabesia and TheileriaIC50 (μg/mL)aEC50 (μg/mL)bSelective indices c
MDBKNIH/3 T3HFFMDBKNIH/3 T3HFF
MEVTB. bovis75.7 ± 2.6930 ± 29.91260 ± 18.9>150012.316.7> 19.8
B. bigemina43.3 ± 1.8930 ± 29.91260 ± 18.9>150021.529.1> 34.6
B. divergens67.6 ± 2.8930 ± 29.91260 ± 18.9>150013.818.6> 22.2
B. caballi48 ± 3.8930 ± 29.91260 ± 18.9>150019.426.3> 31.3
T. equi54 ± 2.1930 ± 29.91260 ± 18.9>150017.223.3> 27.8
AELNB. bovis86.6 ± 8.2573.7 ± 12.4831 ± 19.9>15006.69.6> 17.3
B. bigemina33.3 ± 5.1573.7 ± 12.4831 ± 19.9>150017.225> 45.1
B. divergens62.2 ± 3.3573.7 ± 12.4831 ± 19.9>15009.213.4> 24.1
B. caballi34.5 ± 7.5573.7 ± 12.4831 ± 19.9>150016.624.1> 43.5
T. equi82.2 ± 9.3573.7 ± 12.4831 ± 19.9>1500710.1> 18.2
  1. aIC50 values of MEVT and AELN on all tested parasites in vitro. bEC50 values of MEVT and AELN on the tested cell lines. The dose-response curve using nonlinear regression (curve fit analysis) was used to detect all of these values. The values obtained from the means of triplicate experiments. cSelective index calculated as the ratio between the concentration that causes safety problems in cell lines and the concentration that is used for efficacy in each parasite