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Table 1 IC50 and selective index values of methanolic Viola tricolor and acetonic Laurus nobilis extracts

From: Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Crude extract

Babesia and Theileria

IC50 (μg/mL)a

EC50 (μg/mL)b

Selective indices c

MDBK

NIH/3 T3

HFF

MDBK

NIH/3 T3

HFF

MEVT

B. bovis

75.7 ± 2.6

930 ± 29.9

1260 ± 18.9

>1500

12.3

16.7

> 19.8

B. bigemina

43.3 ± 1.8

930 ± 29.9

1260 ± 18.9

>1500

21.5

29.1

> 34.6

B. divergens

67.6 ± 2.8

930 ± 29.9

1260 ± 18.9

>1500

13.8

18.6

> 22.2

B. caballi

48 ± 3.8

930 ± 29.9

1260 ± 18.9

>1500

19.4

26.3

> 31.3

T. equi

54 ± 2.1

930 ± 29.9

1260 ± 18.9

>1500

17.2

23.3

> 27.8

AELN

B. bovis

86.6 ± 8.2

573.7 ± 12.4

831 ± 19.9

>1500

6.6

9.6

> 17.3

B. bigemina

33.3 ± 5.1

573.7 ± 12.4

831 ± 19.9

>1500

17.2

25

> 45.1

B. divergens

62.2 ± 3.3

573.7 ± 12.4

831 ± 19.9

>1500

9.2

13.4

> 24.1

B. caballi

34.5 ± 7.5

573.7 ± 12.4

831 ± 19.9

>1500

16.6

24.1

> 43.5

T. equi

82.2 ± 9.3

573.7 ± 12.4

831 ± 19.9

>1500

7

10.1

> 18.2

  1. aIC50 values of MEVT and AELN on all tested parasites in vitro. bEC50 values of MEVT and AELN on the tested cell lines. The dose-response curve using nonlinear regression (curve fit analysis) was used to detect all of these values. The values obtained from the means of triplicate experiments. cSelective index calculated as the ratio between the concentration that causes safety problems in cell lines and the concentration that is used for efficacy in each parasite