Table 1 Pharmacokinetic parameters of berberine in Huanglian and Huanglian-Gancao herb pair treated mice (mean ± SD, n = 6)
From: Pharmacokinetic incompatibility of the Huanglian-Gancao herb pair
Samples | Groups | T1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-t (ng·h/mL) | AUC0-∞ (ng·h/mL) | MRT0-t (h) |
|---|---|---|---|---|---|---|---|
Systemic circulation | HL | 14.9 | 2.0 | 38.2 | 244.2 | 623.8 | 5.9 |
HL + Gancao | 3.8 | 2.0 | 46.8 | 211.8 | 242.4 | 3.8 | |
Portal circulation | HL | 2.6 | 2.0 | 104.3 | 425.8 | 440.3 | 2.9 |
HL + Gancao | 4.3 | 2.0 | 76.5 | 270.4 | 297.7 | 3.1 | |
Liver | HL | 3.5 | 2.0 | 4926.1 | 29,500.8 | 33,013.3 | 4.0 |
HL + Gancao | 8.5 | 1.0 | 2642.8 | 15,422.4 | 25,088.6 | 4.9 |