Fig. 1
From: Pharmacokinetic incompatibility of the Huanglian-Gancao herb pair
Concentration-time curves of berberine in blood samples from the systemic circulation (a), portal vein (b), and the liver (c) of mice that received 0.88 g/kg oral Huanglian extract (HLE, 194 mg/kg berberine accordingly) or 2.00 g/kg Huanglian-Gancao extract (HL-GCE, 132 mg/kg berberine accordingly) (mean ± SD, n = 6). The HLE- and HL-GCE-treated groups were administered equal doses of the herb pieces of Huanglian (3 g/kg)