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Table 1 Minimum bactericidal concentration (MBC), minimum inhibitory concentration (MIC) and MBC/MIC ratio of Canarium patentinervium Miq. extracts (mg/ml) and positive control antimicrobial agents (μg/ml) against 4 ATCC bacteria and 9 bacteria and 1 yeast clinical isolates

From: Antibacterial activities of the extracts, fractions and isolated compounds from Canarium patentinervium Miq. against bacterial clinical isolates

Bacteria/ yeastPlant extracts
MBC values (mg/ml)
MIC values (mg/ml)
MBC/MIC ratio, (+) bactericidal; (−) bacteriostatic
Control antimicrobial agents MBC values (mg/ml)
MIC values (mg/ml)
MBC/MIC ratio
LHLCLEBHBCBEPFCFWFAmpicilinAmphotericin
MSSA ATCC 116322
0.5
4(+)
2
2
1(+)
1
1
1(+)
1
1
1(+)
4
0.5
8(−)
4
2
2(+)
1
0.5
2(+)
6.25
1.56
4(+)
NA
MRSA ATCC 433002
0.5
4(+)
4
1
4(+)
4
1
4(+)
2
0.5
4(+)
2
1
2(+)
1
0.5
2(+)
NA
Bacillus cereus ATCC 108761
0.5
2(+)
8
1
8(−)
1
0.5
2(+)
2
0.5
4(+)
2
1
2(+)
2
0.5
4(+)
> 25
6.25
NA
Ps.aeruginosa ATCC 101454
1
4(+)
8
4
2(+)
8
4
2(+)
2
1
2(+)
NA
MSSA4
0.5
8(−)
4
2
2(+)
4
2
2(+)
2
0.5
4(+)
1
0.5
2(+)
4
2
2(+)
2
0.5
4(+)
> 25
> 25
NA
MRSA2
0.25
8(−)
8
2
4(+)
1
0.25
4(+)
4
0.25
16(−)
4
2
2(+)
1
0.25
4(+)
NA
Escherichia coli2
0.5
4(+)
NA
Escherichia coli ESBL> 16/8> 16/8> 16/8NA
Oxacillin-resistant CONS> 16/84
1
4(+)
2
0.5
4(+)
8
2
4(+)
4
0.5
8(−)
2
0.5
4(+)
1
0.5
2(+)
NA
Oxacillin-sensitive CONS> 16/16> 16/82
0.5
4(+)
2
0.5
4(+)
1
0.5
2(+)
12.5
8
1.6(+)
NA
Enterococcus faecalis4
0.5
8(−)
4
0.5
8(−)
2
0.5
4(+)
6.25
3.13
2(+)
NA
Klebsiella species2
0.5
4(+)
16
4
4(+)
16
4
4(+)
2
0.5
4(+)
8
4
2(+)
1
0.5
2(+)
> 25
> 25
NA
Kleb.pneumoniae ESBL2
0.5
4(+)
2
0.5
4(+)
1
0.5
2(+)
NA
Candida parapsilosis8
2
4(+)
> 16
8
8
2
4(+)
8
2
4(+)
16
8
2(+)
4
2
2(+)
NA3.13
0.78
4(+)
  1. LH leaf hexane extract; LC leaf chloroform extract; LE leaf ethanol extract; BH bark hexane extract, BC bark chloroform extract, BE bark ethanol extract; PFpetroleum ether fraction, CF chloroform fraction, WF water fraction, CONS, coagulase-negative staphylococci; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus
  2. -, no activity; NA - not applicable