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Table 5 Inhibitory concentrations of plant extracts against Primary isolates HIV-1UG070 and HIV-1VB59 in TZM-bl and PM1 cell lines

From: In vitro anti-HIV activity of some Indian medicinal plant extracts

Extracts/ Fractions/Controls

TZM-bl assay

PM-1 assay

CC50 (μg/ml)

IC80(μg/ml)

CC50 (μg/ml)

IC80 (μg/ml)

CF

HIV-1

CA

HIV-1

CF

HIV-1

CA

HIV-1

UG

070

VB

59

UG

070

VB

59

UG

070

VB

59

UG

070

VB

59

A. aspera

69

4.8

< 19.53

26

53

10.7

2.6

8.4

1

1.6

F. benghalensis

72

< 78

< 156

< 156

< 78

2.9

3.5

2.9

NA

NA

R. centifolia

132

17

33.5

60.5

> 125

20

3.6

6.8

2.2

9

S. potatorum

124

< 31.25

80

60

105

46

29

NA

6

8.3

F. infectoria

147

18

22

42

73

28

2

29

NA

NA

A. squamosa

51

27

27

25

26

15.12

NA

NA

0.8

0.8

Control

DS

5553

6.43

4.5

–

–

4978

9.18

16.54

–

–

AZT

782

–

–

8.01

18.70

998.5

–

–

8244.35

12,079.33

  1. CC50 50% cytotoxic concentration, IC80 80% inhibitory concentration, DS Dextran Sulphate, AZT Azidothymidine, CF Cell Free, CA Cell Associated
  2. Legend: The plant extracts showing 80% inhibition of HIV-1 primary isolates (UG070 & VB59) in TZM-bl cell line by cell free and cell associated assay with positive controls dextran sulphate and azidothymidine respectively