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Table 9 Effect of CEDL pretreatment on the endogenous antioxidant enzyme system activity, namely CAT and SOD, in the liver of PCM-induced liver intoxication in rats

From: Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Treatment

Dose (mg/kg)

CAT (U/g tissue)

SOD (U/g tissue)

Normal

–

201.6 ± 10.7

167.2 ± 8.1

Negative

–

92.4 ± 8.1a

82.6 ± 9.7a

Positive

50

151.6 ± 9.7ab

129.3 ± 6.6ab

CEDL

50

96.3 ± 8.8a

91.9 ± 9.2a

250

129.6 ± 5.2 ab

122.1 ± 4.9ab

500

193.3 ± 5.8ab

152.6 ± 6.9ab

  1. Normal – Group pretreated and treated with vehicle only; Negative – Group pretreated with vehicle and treated with PCM; Positive – Group pretreated with NAC and treated with PCM; CEDL – Group pretreated with CEDL and treated with PCM
  2. Values are expressed as means ± SEM of six replicates
  3. a Data differed significantly (p < 0.05) when compared against the normal group
  4. b Data differed significantly (p < 0.05) when compared against the negative control group