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Table 8 Tissue hemorrhage scoring of PCM-intoxicated rat’s liver following the oral treatment with vehicle (10% DMSO), 50 mg/kg NAC or, 50, 250 and 500 mg/kg CEDL in comparison to the normal tissue

From: Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Group Dose Number of animals Severity score of tissue hemorrhage Mean ± SEM
mg/kg n 0 1 2 3
Normal 6 6 0 0 0 0
Negative 6 0 0 0 6 3.00 ± 0.00
Positive 50 6 1 3 2 0 1.17 ± 0.31***
CEDL 50 6 0 0 2 4 2.67 ± 0.21
250 6 0 2 3 1 1.83 ± 0.31**
500 6 6 0 0 0 0.17 ± 0.17***
  1. Note: The severity score of tissue hemorrhage was expressed as Mean ± SEM for 6 animals. One-way ANOVA was followed by Dunnett’s post-hoc test, ***p < 0.001, **p < 0.01 vs. vehicle