Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Table 6 Tissue necrosis scoring of PCM-intoxicated rat’s liver following the oral treatment with vehicle (10% DMSO), 50 mg/kg NAC or, 50, 250 and 500 mg/kg CEDL in comparison to the normal tissue

Group	Dose	Number of animals	Severity score of tissue necrosis				Mean ± SEM
Group	mg/kg	n	0	1	2	3	Mean ± SEM
Normal	–	6	6	0	0	0	0
Negative	–	6	0	0	0	6	3.00 ± 0.00
Positive	50	6	0	5	1	0	1.17 ± 0.17***
CEDL	50	6	0	0	1	5	2.83 ± 0.17
	250	6	0	4	2	0	1.33 ± 0.21***
	500	6	5	1	0	0	0.17 ± 0.17***

Note: The severity score of tissue necrosis was expressed as Mean ± SEM for 6 animals. One-way ANOVA was followed by Dunnett’s post-hoc test, ***p < 0.001 vs. vehicle

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