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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Fig. 4

Histopathological observations of PCM-intoxicated liver tissues of rats pretreated with CEDL or NAC at magnification 40x a and 100x b. The liver tissue of normal group shows normal liver architecture, which was damaged by 3 g/kg PCM intoxication as indicated by the occurrence of massive necrosis (N), haemorrhage (H), and inflammation (I). Pretreatment with 5- mg/kg NAC reversed the PCM induced toxicity in the liver tissue by causing mild I evidence by the presence of neutrophils (Neu) and lymphoplasmacytic (LP) cells while the portal tract exerted mild I indicated by the presence of scattered Neu. On the other hand, pretreatment with 50 mg/kg CEDL failed to reverse the effect of PCM as indicated by the presence of a severe H with area of N with the infiltration of I cells and the present of Neu cells. Pretreatment with 250 mg/kg CEDL caused mild I in the liver tissue as indicated by the presence of lymphocytic cells (L) with no area of N and H with the portal tract showing the presence of scattered I cells at the liver parenchyma. Lastly, pretreatment with 500 mg/kg CEDL successfully reversed the toxic effect of PCM on liver tissue as indicated by the absence of H, N and I while the portal tract only showed a mild infiltration of Neu at the liver parenchyma

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