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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Luteolin ameliorates lipopolysaccharide-induced microcirculatory disturbance through inhibiting leukocyte adhesion in rat mesenteric venules

Fig. 6

The proposed mechanism of luteolin on suppressing microcirculatory disturbance caused by cell adhesion. Luteolin could decrease the expression of adhesion molecules and pro-inflammatory cytokines by inhibiting LPS/TLR4/NF-κB signaling pathway, which would suppress LPS-induced leukocyte adhesion. Subsequently, the other processes of microcirculatory disturbance induced by LPS such as hydrogen peroxide production, mast cell degranulation, blood flow reduced and mesenteric artery pathological changes were also improved

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