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Table 1 Effect of green coffee, silymarin and their combination on ALT, AST, ALP), total protein (TP), albumin, bilirubin, creatinine, uric acid (UA), blood urea nitrogen (BUN) and lipids in CCl4 induced hepatotoxic rats

From: Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats

  ALP
(U/L)
AST
(Ul)
ALT
(U/l)
Cholesterol
(mg/dl)
TG
(mg/dl)
HDL
(mg/dl)
LDL
(mg/dl)
BUN
(mg/dl)
UA
(mg/dl)
Creatinine
(mg/dl)
Bilirubin
(mg/dl)
TP
(g/dl)
Albumin
(g/dl)
LDH
(U/L)
Negative control group
(G1)
164.0 ± 8.62# 22.33 ± 2.8# 21.66 ± 3.55# 163.5 ± 6.89# 134.0 ± 11.34# 90.36 ± 6.44# 46.33 ± 1.63# 22.0 ± 2.6# 4.25 ± 0.18# 0.71 ± 0.15# 0.42 ± 0.03# 6.5 ± 0.14# 5.43 ± 0.28# 175.16 ± 12.54#
Positive control group
(Group 2)
283.33 ± 6.94* 91.83 ± 5.49* 98.5 ± 5.2* 277.33 ± 7.11* 250.83 ± 8.28* 18.66 ± 1.75* 208.0 ± 7.72* 64.0 ± 3.22* 7.28 ± 0.29* 2.51 ± 0.28* 1.51 ± 0.19* 3.5 ± 0.28* 2.31 ± 0.2* 446.0 ± 8.94*
Green coffee methanolic extract
(Group 3)
254.33 ± 5.35*# 76.33 ± 2.16*# 84.66 ± 3.14*# 258.5 ± 5.46*# 222.66 ± 3.72*# 32.0 ± 1.54*# 183.0 ± 6.44*# 56.83 ± 1.94*# 6.86 ± 0.1*# 1.93 ± 0.1*# 0.89 ± 0.04*# 4.38 ± 0.2*# 2.96 ± 0.15*# 404.0 ± 8.89*#
Silymarin
(Group 4)
190.0 ± 4.89*# 53.33 ± 4.22*# 54.83 ± 3.43*# 223.33 ± 4.92*# 197.16 ± 5.49*# 34.5 ± 2.16*# 149.16 ± 4.99*# 46.0 ± 2.09*# 5.98 ± 0.16*# 1.3 ± 0.14*# 0.67 ± 0.01*# 5.08 ± 0.14* 4.1 ± 0.12*# 360.5 ± 5.78*#
Combination of green coffee methanolic extract and silymarin
(Group 5)
164.16 ± 5.52# 40.33 ± 1.21*# 45.0 ± 2.0*# 204.33 ± 7.68*# 178.5 ± 6.7*# 40.33 ± 1.21*# 127.83 ± 6.3*# 35.83 ± 2.22*# 5.23 ± 0.12*# 0.855 ± 0.018# 0.54 ± 0.025# 5.95 ± 0.23*# 4.78 ± 0.17*# 214.16 ± 7.25*#
Negative control group
(G1)
164.0 ± 8.62# 22.33 ± 2.8# 21.66 ± 3.55# 163.5 ± 6.89# 134.0 ± 11.34# 90.36 ± 6.44# 46.33 ± 1.63# 22.0 ± 2.6# 4.25 ± 0.18# 0.71 ± 0.65# 0.42 ± 0.03# 6.5 ± 0.14# 5.43 ± 0.28# 175.16 ± 12.54#
Positive control group
(Group 2)
283.33 ± 6.94* 91.83 ± 5.49* 98.5 ± 5.2* 277.33 ± 7.11* 250.83 ± 8.28* 18.66 ± 1.75* 208.0 ± 7.72* 64.0 ± 3.22* 7.28 ± 0.29* 2.51 ± 0.28* 1.51 ± 0.19* 3.5 ± 0.28* 2.31 ± 0.2* 446.0 ± 8.94*
Green coffee methanolic extract
(Group 3)
254.33 ± 5.35*# 76.33 ± 2.16*# 84.66 ± 3.14*# 258.5 ± 5.46*# 222.66 ± 3.72*# 32.0 ± 1.54*# 183.0 ± 6.44*# 56.83 ± 1.94*# 6.86 ± 0.1*# 1.93 ± 0.1*# 0.89 ± 0.04*# 4.38 ± 0.2*# 2.96 ± 0.15*# 404.0 ± 8.89*#
Silymarin
(Group 4)
190.0 ± 4.89*# 53.33 ± 4.22*# 54.83 ± 3.43*# 223.33 ± 4.92*# 197.16 ± 5.49*# 34.5 ± 2.16*# 149.16 ± 4.99*# 46.0 ± 2.09*# 5.98 ± 0.16*# 1.3 ± 0.14*# 0.67 ± 0.01*# 5.08 ± 0.14* 4.1 ± 0.12*# 360.5 ± 5.78*#
Combination of green coffee methanolic extract and silymarin
(Group 5)
164.16 ± 5.52# 40.33 ± 1.21*# 45.0 ± 2.0*# 204.33 ± 7.68*# 178.5 ± 6.7*# 40.33 ± 1.21*# 127.83 ± 6.3*# 35.83 ± 2.22*# 5.23 ± 0.12*# 0.855 ± 0.018# 0.54 ± 0.025# 5.95 ± 0.23*# 4.78 ± 0.17*# 214.16 ± 7.25*#
Negative control group
(G1)
164.0 ± 8.62# 22.33 ± 2.8# 21.66 ± 3.55# 163.5 ± 6.89# 134.0 ± 11.34# 90.36 ± 6.44# 46.33 ± 1.63# 22.0 ± 2.6# 4.25 ± 0.18# 0.71 ± 0.65# 0.42 ± 0.03# 6.5 ± 0.14# 5.43 ± 0.28# 175.16 ± 12.54#
Positive control group
(Group 2)
283.33 ± 6.94* 91.83 ± 5.49* 98.5 ± 5.2* 277.33 ± 7.11* 250.83 ± 8.28* 18.66 ± 1.75* 208.0 ± 7.72* 64.0 ± 3.22* 7.28 ± 0.29* 2.51 ± 0.28* 1.51 ± 0.19* 3.5 ± 0.28* 2.31 ± 0.2* 446.0 ± 8.94*
Green coffee methanolic extract
(Group 3)
254.33 ± 5.35*# 76.33 ± 2.16*# 84.66 ± 3.14*# 258.5 ± 5.46*# 222.66 ± 3.72*# 32.0 ± 1.54*# 183.0 ± 6.44*# 56.83 ± 1.94*# 6.86 ± 0.1*# 1.93 ± 0.1*# 0.89 ± 0.04*# 4.38 ± 0.2*# 2.96 ± 0.15*# 404.0 ± 8.89*#
Silymarin
(Group 4)
190.0 ± 4.89*# 53.33 ± 4.22*# 54.83 ± 3.43*# 223.33 ± 4.92*# 197.16 ± 5.49*# 34.5 ± 2.16*# 149.16 ± 4.99*# 46.0 ± 2.09*# 5.98 ± 0.16*# 1.3 ± 0.14*# 0.67 ± 0.01*# 5.08 ± 0.14* 4.1 ± 0.12*# 360.5 ± 5.78*#
Combination of green coffee methanolic extract and silymarin
(Group 5)
164.16 ± 5.52# 40.33 ± 1.21*# 45.0 ± 2.0*# 204.33 ± 7.68*# 178.5 ± 6.7*# 40.33 ± 1.21*# 127.83 ± 6.3*# 35.83 ± 2.22*# 5.23 ± 0.12*# 0.855 ± 0.018# 0.54 ± 0.025# 5.95 ± 0.23*# 4.78 ± 0.17*# 214.16 ± 7.25*#
Negative control group
(G1)
164.0 ± 8.62# 22.33 ± 2.8# 21.66 ± 3.55# 163.5 ± 6.89# 134.0 ± 11.34# 90.36 ± 6.44# 46.33 ± 1.63# 22.0 ± 2.6# 4.25 ± 0.18# 0.71 ± 0.65# 0.42 ± 0.03# 6.5 ± 0.14# 5.43 ± 0.28# 175.16 ± 12.54#
Positive control group
(Group 2)
283.33 ± 6.94* 91.83 ± 5.49* 98.5 ± 5.2* 277.33 ± 7.11* 250.83 ± 8.28* 18.66 ± 1.75* 208.0 ± 7.72* 64.0 ± 3.22* 7.28 ± 0.29* 2.51 ± 0.28* 1.51 ± 0.19* 3.5 ± 0.28* 2.31 ± 0.2* 446.0 ± 8.94*
Green coffee methanolic extract
(Group 3)
254.33 ± 5.35*# 76.33 ± 2.16*# 84.66 ± 3.14*# 258.5 ± 5.46*# 222.66 ± 3.72*# 32.0 ± 1.54*# 183.0 ± 6.44*# 56.83 ± 1.94*# 6.86 ± 0.1*# 1.93 ± 0.1*# 0.89 ± 0.04*# 4.38 ± 0.2*# 2.96 ± 0.15*# 404.0 ± 8.89*#
Silymarin
(Group 4)
190.0 ± 4.89*# 53.33 ± 4.22*# 54.83 ± 3.43*# 223.33 ± 4.92*# 197.16 ± 5.49*# 34.5 ± 2.16*# 149.16 ± 4.99*# 46.0 ± 2.09*# 5.98 ± 0.16*# 1.3 ± 0.14*# 0.67 ± 0.01*# 5.08 ± 0.14* 4.1 ± 0.12*# 360.5 ± 5.78*#
Combination of green coffee methanolic extract and silymarin
(Group 5)
164.16 ± 5.52# 40.33 ± 1.21*# 45.0 ± 2.0*# 204.33 ± 7.68*# 178.5 ± 6.7*# 40.33 ± 1.21*# 127.83 ± 6.3*# 35.83 ± 2.22*# 5.23 ± 0.12*# 0.855 ± 0.018# 0.54 ± 0.025# 5.95 ± 0.23*# 4.78 ± 0.17*# 214.16 ± 7.25*#
  1. The results are expressed as the M ± SD. * shows a statistically significant difference (P < 0.05) and # significant at p < 0.05 compared with the positive control group (G2)