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Table 4 Effects of male treatment with PADE on fetal development

From: Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

Parameters Study groupsa
Control, H2O PADE, 25 mg/kg PADE, 125 mg/kg
Fetal development on day 20 post fertilization (mean + SD)
 No. of dams examined 5 8 8
 No. corpus luteum/dam 12.6 + 0.7 11.3 + 0.8 12.3 + 0.6
 No. implantations/dam 11.0 + 0.8 9.9 + 0.6 10.5 + 0.6
 No. live fetuses/dam 10.2 + 0.7 9.0 + 0.3 9.9 + 0.8
 No. resorptions/ dam 0.8 + 0.3 0.9 + 0.5 0.6 + 0.3
 Fetal weight, (g) 2.4 + 0.1 2.3 + 0.1 2.3 + 0.1
 Pre-implantation death (%) 12.7 12.4 14.6
 Post-implantation death (%) 7.3 9.1 5.7
  1. aMale rats were treated with either H2O (control) or PADE (25 or 125 mg/kg) for 60 days before mating