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Table 2 PADE gonadotropic effects

From: Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

Parameters Study groupsa
Control PADE, 25 mg/kg PADE, 125 mg/kg
Total number of spermatozoa (× 106) 591.1+  37.2 599.4 + 35.5 481.2 + 54.5
Motile spermatozoa (×106) 327.8 + 18.6 240.6 + 26.6** 163.3 + 29.1**
Motile spermatozoa (%) 56.1 + 2.9 46.3 + 1.7** 32.8 + 3.3**
Duration of spermatozoon movement (min.) 170.0 + 13.5 162.5 + 16.0 98.0 + 11.4**
Pathologic forms of spermatozoa (%) 1.5+  0.3 2.7 + 0.2** 5.1 + 0.5**
Testicular weight (g) 3.2 + 0.1 3.3 + 0.1 3.4 + 0.2
Relative testicular weight (%) 0.76 + 0.04 0.82 + 0.02 0.90 + 0.04
Spermatogenesis index, Median (range) 3.36 (3.28,3.42) 3.08 (3.04,3.11) ** 3.02 (3.0,3.05) **
  1. aMale rats were treated with either H2O (control) or PADE (25 or 125 mg/kg) for 60 days before mating; **p < 0.05