Fig. 4

Effect of drug treatment on ethanol withdrawal anxiety when tested on the elevated plus-maze in rats. a Number of entries in the closed arm. b Time spent in the closed arm. c Number of entries in the open arm. d Time spent in the open arm. *p < 0.05, **p < 0.01, ***p < 0.001 (Compared to normal control); #p < 0.05, ##p < 0.01, ###p < 0.001 (Compared to disease control); One-way ANOVA; Dunnett’s multiple comparison test. G1-Normal Control, G2-Disease Control, G3-POL-6 treatment (20 mg/kg), G4-POL-6 treatment (50 mg/kg), G5-POL-6 treatment (100 mg/kg), G6-Standard (Diazepam 2 mg/kg)