Fig. 6

PKC-δ silencing improves insulin resistance in FFA-induced L02 hepatocyte. Control siRNA group (NC), control siRNA + FFA group (NF), control siRNA + FFA + 10% high dose of HQT-medicated serum group (NH), PKC-δ siRNA group (SC), PKC-δ siRNA + FFA group (SF) and PKC-δ siRNA + FFA + 10% high dose of HQT-medicated serum group (SH). a and b Levels of IL-1β and TNFα induced by FFA in L02 cells with or without transfection of PKC-δ siRNA. c ROS level. d and e Glucose consumption with/without 100 nmol/L insulin treatments. f and g The expression levels of PI3K-p85, AKT, and p-AKT protein in L02 cells with or without transfection of PKC-δ siRNA. Results are expressed as mean ± S.D. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs NC group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs NF group; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001, vs SC group; ^&* p < 0.05, ^&&* p < 0.01, ^&&* p < 0.01 vs SF group