TY - JOUR AU - Huang, Chien-Ning AU - Wang, Chau-Jong AU - Lin, Chih-Li AU - Li, Hsin-Hua AU - Yen, An-Ting AU - Peng, Chiung-Huei PY - 2020 DA - 2020/12/02 TI - Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals JO - BMC Complementary Medicine and Therapies SP - 370 VL - 20 IS - 1 AB - Insulin resistance could be associated with the development of Alzheimer disease (AD). The neuropathological hallmarks of AD are beta amyloid (Aβ) produced from sequential cleavage initiated by β-secretase and degraded by insulin degradation enzyme (IDE), as well as hyperphosphorylation of tau (p-tau). Insulin action involves the cascades of insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K), while phosphorylation of IRS-1 at ser307 (p-ser307IRS-1) hinders the response. Our previous report suggested dipeptidyl peptidase-4 (DPP-4) is crucial to insulin resistance, and the subfractions of Abelmoschus esculentus (AE), F1 and F2, attenuate the signaling. Here we aim to investigate whether AE works to reduce Aβ generation via regulating DPP4 and insulin resistance. SN - 2662-7671 UR - https://doi.org/10.1186/s12906-020-03163-4 DO - 10.1186/s12906-020-03163-4 ID - Huang2020 ER -