TY - STD TI - The American Cancer Society. Cancer Facts & Figures 2014 http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures 2014/2014. UR - http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures ID - ref1 ER - TY - JOUR AU - Arnold, M. AU - Sierra, M. S. AU - Laversanne, M. AU - Soerjomataram, I. AU - Jemal, A. AU - Bray, F. PY - 2017 DA - 2017// TI - Global patterns and trends in colorectal cancer incidence and mortality JO - Gut. VL - 66 UR - https://doi.org/10.1136/gutjnl-2015-310912 DO - 10.1136/gutjnl-2015-310912 ID - Arnold2017 ER - TY - STD TI - World Health Organisation. Cancer 2018 https://www.who.int/health-topics/cancer#tab=tab_1. UR - https://www.who.int/health-topics/cancer#tab=tab_1 ID - ref3 ER - TY - JOUR AU - Binefa, G. AU - Rodriguez-Moranta, F. AU - Teule, A. AU - Medina-Hayas, M. PY - 2014 DA - 2014// TI - Colorectal cancer: from prevention to personalized medicine JO - World J Gastroenterol VL - 20 UR - https://doi.org/10.3748/wjg.v20.i22.6786 DO - 10.3748/wjg.v20.i22.6786 ID - Binefa2014 ER - TY - JOUR AU - Brouwer, N. P. M. AU - Bos, A. AU - Lemmens, V. AU - Tanis, P. J. AU - Hugen, N. AU - Nagtegaal, I. D. AU - Wilt, J. H. W. AU - Verhoeven, R. H. A. PY - 2018 DA - 2018// TI - An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients JO - Int J Cancer VL - 143 UR - https://doi.org/10.1002/ijc.31785 DO - 10.1002/ijc.31785 ID - Brouwer2018 ER - TY - JOUR AU - Inada, R. AU - Nagasaka, T. AU - Watanabe, A. AU - Yagi, T. AU - Mori, Y. AU - Kondo, Y. AU - Kishimoto, H. AU - Umeda, Y. AU - Fujiwara, T. PY - 2017 DA - 2017// TI - Comparison of outcomes between symptomatic and asymptomatic patients with colorectal cancer: a propensity score-matched analysis of surgical invasiveness, medical costs and oncological outcomes JO - BMJ Open Gastroenterol VL - 4 UR - https://doi.org/10.1136/bmjgast-2017-000146 DO - 10.1136/bmjgast-2017-000146 ID - Inada2017 ER - TY - JOUR AU - Jeught, K. AU - Xu, H. C. AU - Li, Y. J. AU - Lu, X. B. AU - Ji, G. PY - 2018 DA - 2018// TI - Drug resistance and new therapies in colorectal cancer JO - World J Gastroenterol VL - 24 UR - https://doi.org/10.3748/wjg.v24.i34.3834 DO - 10.3748/wjg.v24.i34.3834 ID - Jeught2018 ER - TY - JOUR AU - Nurgali, K. AU - Jagoe, R. T. AU - Abalo, R. PY - 2018 DA - 2018// TI - Editorial: adverse effects of Cancer chemotherapy: anything new to improve tolerance and reduce Sequelae? JO - Front Pharmacol VL - 9 UR - https://doi.org/10.3389/fphar.2018.00245 DO - 10.3389/fphar.2018.00245 ID - Nurgali2018 ER - TY - JOUR AU - Volpato, M. AU - Hull, M. A. PY - 2018 DA - 2018// TI - Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer JO - Cancer Metastasis Rev VL - 37 UR - https://doi.org/10.1007/s10555-018-9744-y DO - 10.1007/s10555-018-9744-y ID - Volpato2018 ER - TY - JOUR AU - Morin-Ben, S. H. V. PY - 2017 DA - 2017// TI - Epidermal Growth Factor Receptor Tyrosine Kinase Inhibiters in Treatment of Metastatic Non-Small Cell Lung Cancer,with a Focus on Afatinib JO - Front Oncol VL - 7 UR - https://doi.org/10.3389/fonc.2017.00097 DO - 10.3389/fonc.2017.00097 ID - Morin-Ben2017 ER - TY - JOUR AU - Fluckiger, A. AU - Dumont, A. AU - Derangere, V. AU - Rebe, C. AU - Rosny, C. AU - Causse, S. PY - 2016 DA - 2016// TI - Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFalpha JO - Oncogene. VL - 35 UR - https://doi.org/10.1038/onc.2015.523 DO - 10.1038/onc.2015.523 ID - Fluckiger2016 ER - TY - JOUR AU - Miccadei, S. AU - Masella, R. AU - Mileo, A. M. AU - Gessani, S. PY - 2016 DA - 2016// TI - Omega3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies JO - Frontiers Immunol VL - 7 UR - https://doi.org/10.3389/fimmu.2016.00486 DO - 10.3389/fimmu.2016.00486 ID - Miccadei2016 ER - TY - JOUR AU - Tou, J. C. AU - Jaczynski, J. AU - Chen, Y. C. PY - 2007 DA - 2007// TI - Krill for human consumption: nutritional value and potential health benefits JO - Nutr Rev VL - 65 UR - https://doi.org/10.1111/j.1753-4887.2007.tb00283.x DO - 10.1111/j.1753-4887.2007.tb00283.x ID - Tou2007 ER - TY - JOUR AU - Winther, B. AU - Hoem, N. AU - Berge, K. AU - Reubsaet, L. PY - 2011 DA - 2011// TI - Elucidation of phosphatidylcholine composition in krill oil extracted from Euphausia superba JO - Lipids. VL - 46 UR - https://doi.org/10.1007/s11745-010-3472-6 DO - 10.1007/s11745-010-3472-6 ID - Winther2011 ER - TY - JOUR AU - Sung, H. H. AU - Sinclair, A. J. AU - Lewandowski, P. A. AU - Su, X. Q. PY - 2018 DA - 2018// TI - Postprandial long-chain n-3 polyunsaturated fatty acid response to krill oil and fish oil consumption in healthy women: a randomised controlled, single-dose, crossover study JO - Asia Pac J Clin Nutr VL - 27 ID - Sung2018 ER - TY - JOUR AU - Ulven, S. M. AU - Kirkhus, B. AU - Lamglait, A. AU - Basu, S. AU - Elind, E. AU - Haider, T. AU - Berge, K. AU - Vic, H. AU - Pedersen, J. I. PY - 2011 DA - 2011// TI - Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers JO - Lipids. VL - 46 UR - https://doi.org/10.1007/s11745-010-3490-4 DO - 10.1007/s11745-010-3490-4 ID - Ulven2011 ER - TY - JOUR AU - Su, X. U. AU - Tanalgo, P. AU - Bustos, M. AU - Dass, C. R. PY - 2018 DA - 2018// TI - The effect of krill oil and n-3 polyunsaturated fatty acids on human osteosarcoma cell proliferation and migration JO - Curr Drug Targets. VL - 19 UR - https://doi.org/10.2174/1389450116666150107152206 DO - 10.2174/1389450116666150107152206 ID - Su2018 ER - TY - JOUR AU - Jayathilake, A. G. AU - Senior, P. V. AU - Su, X. Q. PY - 2016 DA - 2016// TI - Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells JO - BMC Complement Altern Med VL - 16 UR - https://doi.org/10.1186/s12906-016-1311-x DO - 10.1186/s12906-016-1311-x ID - Jayathilake2016 ER - TY - JOUR AU - Jayathilake, A. G. AU - Kadife, E. AU - Luwor, R. B. AU - Nurgali, K. AU - Su, X. Q. PY - 2019 DA - 2019// TI - Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9 JO - Nutr Metab (Lond) VL - 16 UR - https://doi.org/10.1186/s12986-019-0382-3 DO - 10.1186/s12986-019-0382-3 ID - Jayathilake2019 ER - TY - JOUR AU - Zhu, J. J. AU - Shi, J. H. AU - Qian, W. B. AU - Cai, Z. Z. AU - Li, D. PY - 2008 DA - 2008// TI - Effects of krill oil on serum lipids of hyperlipidemic rats and human SW480 cells JO - Lipids Health Dis VL - 7 UR - https://doi.org/10.1186/1476-511X-7-30 DO - 10.1186/1476-511X-7-30 ID - Zhu2008 ER - TY - JOUR AU - Voldborg, B. R. AU - Damstrup, L. AU - Spang-Thomsen, M. AU - Poulsen, H. S. PY - 1997 DA - 1997// TI - Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials JO - Ann Oncol VL - 8 UR - https://doi.org/10.1023/A:1008209720526 DO - 10.1023/A:1008209720526 ID - Voldborg1997 ER - TY - JOUR AU - Sasaki, T. AU - Hiroki, K. AU - Yamashita, Y. PY - 2013 DA - 2013// TI - The role of epidermal growth factor receptor in cancer metastasis and microenvironment JO - Biomed Res Int VL - 2013 UR - https://doi.org/10.1155/2013/546318 DO - 10.1155/2013/546318 ID - Sasaki2013 ER - TY - JOUR AU - Roberts, R. B. AU - Min, L. AU - Washington, M. K. AU - Olsen, S. J. AU - Settle, S. H. AU - Coffey, R. J. AU - Threadgill, D. W. PY - 2002 DA - 2002// TI - Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.032678499 DO - 10.1073/pnas.032678499 ID - Roberts2002 ER - TY - JOUR AU - Crane, C. A. AU - Panner, A. AU - Murray, J. C. AU - Wilson, S. P. AU - Xu, H. AU - Chen, L. AU - Simko, J. P. AU - Waldman, F. M. AU - Pieper, R. O. AU - Parsa, A. T. PY - 2009 DA - 2009// TI - PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer JO - Oncogene. VL - 28 UR - https://doi.org/10.1038/onc.2008.384 DO - 10.1038/onc.2008.384 ID - Crane2009 ER - TY - JOUR AU - Parsa, A. T. AU - Waldron, J. S. AU - Panner, A. AU - Crane, C. A. AU - Parney, I. F. AU - Barry, J. J. AU - Cachola, K. E. AU - Murray, J. C. AU - Tihan, T. AU - Jensen, M. C. AU - Mischel, P. S. AU - Stokoe, D. AU - Pieper, R. O. PY - 2007 DA - 2007// TI - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma JO - Nat Med VL - 13 UR - https://doi.org/10.1038/nm1517 DO - 10.1038/nm1517 ID - Parsa2007 ER - TY - STD TI - Ding Y, Mullapudi B, Torres C, Mascarinas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adraian K, DeCant B, Rao S, Ouellette M, Taso MS, Bentrem DJ, Grippo PJ. Omega-3 fatty acids prevent early pancreatic carcinogenesis via repression of the AKT pathway. Nutrients. 2018;10(9):1289. https://doi.org/10.3390/nu10091289. ID - ref26 ER - TY - STD TI - Escors DG-CM, Zuazo M, Arasanz H, Garcia-Granda MJ, Vera R, Kochan G. The intracellular signalosome of PD-L1 in cancer cells. Signal transcuct Target Therap. 2018;3:26. https://doi.org/10.1038/s41392-018-0022-9. ID - ref27 ER - TY - JOUR AU - Salimon, J. AU - Abdullah, B. M. AU - Salih, N. PY - 2011 DA - 2011// TI - Hydrolysis optimization and characterization study of preparing fatty acids from Jatropha curcas seed oil JO - Chem Cent J VL - 5 UR - https://doi.org/10.1186/1752-153X-5-67 DO - 10.1186/1752-153X-5-67 ID - Salimon2011 ER - TY - JOUR AU - Xie, D. G. M. AU - Wei, W. AU - Jin, J. AU - Wang, X. AU - Wang, X. AU - Jin, Q. PY - 2019 DA - 2019// TI - Antarctic krill (Euphausia superba) oil: a comprehensive review of chemical composition, extraction technologies, health benefits, and current application JO - Compr Rev Food Sci Food Saf VL - 18 UR - https://doi.org/10.1111/1541-4337.12427 DO - 10.1111/1541-4337.12427 ID - Xie2019 ER - TY - JOUR AU - Zheng, W. AU - Wang, X. AU - Cao, W. AU - Yang, B. AU - Mu, Y. AU - Dong, Y. PY - 2017 DA - 2017// TI - E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro JO - Prostaglandins Leukot Essent Fatty Acids. VL - 117 UR - https://doi.org/10.1016/j.plefa.2017.01.005 DO - 10.1016/j.plefa.2017.01.005 ID - Zheng2017 ER - TY - JOUR AU - Zheng, W. AU - Li, J. AU - Wang, X. AU - Yuan, Y. AU - Zhang, J. AU - Xiu, Z. PY - 2018 DA - 2018// TI - Effects of Antarctic krill docosahexaenoic acid on MCF-7 cell migration and invasion induced by the interaction of CD95 with caveolin-1 JO - Life Sci VL - 192 UR - https://doi.org/10.1016/j.lfs.2017.11.011 DO - 10.1016/j.lfs.2017.11.011 ID - Zheng2018 ER - TY - JOUR AU - Lee, J. Y. AU - Sim, T. B. AU - Lee, J. E. AU - Na, H. K. PY - 2017 DA - 2017// TI - Chemopreventive and chemotherapeutic effects of fish oil derived Omega-3 polyunsaturated fatty acids on Colon carcinogenesis JO - Clinical nutrition research VL - 6 UR - https://doi.org/10.7762/cnr.2017.6.3.147 DO - 10.7762/cnr.2017.6.3.147 ID - Lee2017 ER - TY - JOUR AU - Eltweri, A. M. AU - Thomas, A. L. AU - Metcalfe, M. AU - Calder, P. C. AU - Dennison, A. R. AU - Bowrey, D. J. PY - 2016 DA - 2016// TI - Potential applications of fish oils rich in omega-3 polyunsaturated fatty acids in the management of gastrointestinal cancer JO - Clin Nutr VL - 36 UR - https://doi.org/10.1016/j.clnu.2016.01.007 DO - 10.1016/j.clnu.2016.01.007 ID - Eltweri2016 ER - TY - JOUR AU - Park, J. M. AU - Kwon, S. H. AU - Han, Y. M. AU - Hahm, K. B. AU - Kim, E. H. PY - 2013 DA - 2013// TI - Omega-3 polyunsaturated fatty acids as potential chemopreventive agent for gastrointestinal cancer JO - J Cancer Prevention VL - 18 UR - https://doi.org/10.15430/JCP.2013.18.3.201 DO - 10.15430/JCP.2013.18.3.201 ID - Park2013 ER - TY - JOUR AU - Fuentes, N. R. AU - Salinas, M. L. AU - Kim, E. AU - Chapkin, R. S. PY - 2017 DA - 2017// TI - Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization JO - Biochim Biophys Acta Biomembr VL - 1859 UR - https://doi.org/10.1016/j.bbamem.2017.03.014 DO - 10.1016/j.bbamem.2017.03.014 ID - Fuentes2017 ER - TY - JOUR AU - Michalak, A. AU - Mosinska, P. AU - Fichna, J. PY - 2016 DA - 2016// TI - Polyunsaturated fatty acids and their derivatives: therapeutic value for inflammatory, functional gastrointestinal disorders, and colorectal Cancer JO - Front Pharmacol VL - 7 UR - https://doi.org/10.3389/fphar.2016.00459 DO - 10.3389/fphar.2016.00459 ID - Michalak2016 ER - TY - STD TI - D’Eliseo D, Velotti F. Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy. J Clin Med. 2016;5(2):15. https://doi.org/10.3390/jcm5020015. ID - ref37 ER - TY - JOUR AU - Zhang, C. AU - Yu, H. AU - Ni, X. AU - Shen, S. AU - Das, U. N. PY - 2015 DA - 2015// TI - Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0123256 DO - 10.1371/journal.pone.0123256 ID - Zhang2015 ER - TY - JOUR AU - Giros, A. AU - Grzybowski, M. AU - Sohn, V. R. AU - Pons, E. AU - Fernandez-Morales, J. AU - Xicola, R. M. AU - Sethi, P. AU - Grzybowski, J. AU - Goel, A. AU - Boland, C. R. AU - Gassull, M. A. AU - Llor, X. PY - 2009 DA - 2009// TI - Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic JO - Cancer Prev Res (Phila) VL - 2 UR - https://doi.org/10.1158/1940-6207.CAPR-08-0197 DO - 10.1158/1940-6207.CAPR-08-0197 ID - Giros2009 ER - TY - JOUR AU - Cockbain, A. J. AU - Toogood, G. J. AU - Hull, M. A. PY - 2012 DA - 2012// TI - Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer JO - Gut. VL - 61 UR - https://doi.org/10.1136/gut.2010.233718 DO - 10.1136/gut.2010.233718 ID - Cockbain2012 ER - TY - JOUR AU - Rogers, K. R. AU - Kikawa, K. D. AU - Mouradian, M. AU - Hernandez, K. AU - McKinnon, K. M. AU - Ahwah, S. M. AU - Pardini, R. S. PY - 2010 DA - 2010// TI - Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association JO - Carcinogenesis. VL - 31 UR - https://doi.org/10.1093/carcin/bgq111 DO - 10.1093/carcin/bgq111 ID - Rogers2010 ER - TY - JOUR AU - Turk, H. F. AU - Chapkin, R. S. PY - 2013 DA - 2013// TI - Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 88 UR - https://doi.org/10.1016/j.plefa.2012.03.008 DO - 10.1016/j.plefa.2012.03.008 ID - Turk2013 ER - TY - JOUR AU - Matucci-Cerinic, M. AU - Casini, A. PY - 1988 DA - 1988// TI - Ketoprofen vs etofenamate in a controlled double-blind study: evidence of topical effectiveness in soft tissue rheumatic pain JO - Int J Clin Pharmacol Res VL - 8 ID - Matucci-Cerinic1988 ER - TY - JOUR AU - Jonker, D. J. AU - O'Callaghan, C. J. AU - Karapetis, C. S. AU - Zalcberg, J. R. AU - Tu, D. AU - Au, H. J. AU - Berry, R. AU - Krahn, M. AU - Price, T. AU - Simes, R. J. AU - Tebbutt, N. C. AU - Hazel, G. AU - Wierzbicki, R. AU - Langer, C. AU - Moore, M. J. PY - 2007 DA - 2007// TI - Cetuximab for the treatment of colorectal cancer JO - N Engl J Med VL - 357 UR - https://doi.org/10.1056/NEJMoa071834 DO - 10.1056/NEJMoa071834 ID - Jonker2007 ER - TY - JOUR AU - Schley, P. D. AU - Jijon, H. B. AU - Robinson, L. E. AU - Field, C. J. PY - 2005 DA - 2005// TI - Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells JO - Breast Cancer Res Treat VL - 92 UR - https://doi.org/10.1007/s10549-005-2415-z DO - 10.1007/s10549-005-2415-z ID - Schley2005 ER - TY - JOUR AU - Mebratu, Y. AU - Tesfaigzi, Y. PY - 2009 DA - 2009// TI - How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer? JO - Cell Cycle VL - 8 UR - https://doi.org/10.4161/cc.8.8.8147 DO - 10.4161/cc.8.8.8147 ID - Mebratu2009 ER - TY - JOUR AU - Zhang, Z. AU - Zhou, X. AU - Shen, H. AU - Wang, D. AU - Wang, Y. PY - 2009 DA - 2009// TI - Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitro study JO - BMC Med VL - 7 UR - https://doi.org/10.1186/1741-7015-7-41 DO - 10.1186/1741-7015-7-41 ID - Zhang2009 ER - TY - JOUR AU - Millington, G. W. PY - 2013 DA - 2013// TI - Mutations of the BRAF gene in human cancer, by Davies et al. (nature 2002; 417: 949-54) JO - Clin Exp Dermatol VL - 38 UR - https://doi.org/10.1111/ced.12015 DO - 10.1111/ced.12015 ID - Millington2013 ER - TY - JOUR AU - Sun, H. AU - Hu, Y. AU - Gu, Z. AU - Owens, R. T. AU - Chen, Y. Q. AU - Edwards, I. J. PY - 2011 DA - 2011// TI - Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway JO - Carcinogenesis. VL - 32 UR - https://doi.org/10.1093/carcin/bgr132 DO - 10.1093/carcin/bgr132 ID - Sun2011 ER - TY - JOUR AU - Cao, W. AU - Ma, Z. AU - Rasenick, M. M. AU - Yeh, S. AU - Yu, J. PY - 2012 DA - 2012// TI - N-3 poly-unsaturated fatty acids shift estrogen signaling to inhibit human breast cancer cell growth JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0052838 DO - 10.1371/journal.pone.0052838 ID - Cao2012 ER - TY - JOUR AU - Serini, S. AU - Ottes Vasconcelos, R. AU - Fasano, E. AU - Calviello, G. PY - 2016 DA - 2016// TI - Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer JO - Expert Opin Ther Targets VL - 20 UR - https://doi.org/10.1517/14728222.2016.1139085 DO - 10.1517/14728222.2016.1139085 ID - Serini2016 ER - TY - JOUR AU - Akinleye, A. AU - Avvaru, P. AU - Furqan, M. AU - Song, Y. AU - Liu, D. PY - 2013 DA - 2013// TI - Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics JO - J Hematol Oncol VL - 6 UR - https://doi.org/10.1186/1756-8722-6-88 DO - 10.1186/1756-8722-6-88 ID - Akinleye2013 ER - TY - JOUR AU - Liu, P. AU - Cheng, H. AU - Roberts, T. M. AU - Zhao, J. J. PY - 2009 DA - 2009// TI - Targeting the phosphoinositide 3-kinase pathway in cancer JO - Nat Rev Drug Discov VL - 8 UR - https://doi.org/10.1038/nrd2926 DO - 10.1038/nrd2926 ID - Liu2009 ER - TY - STD TI - Szymonowicz K, Oeck S, Malewicz NM, Jendrossek V. New insights into protein kinase b/akt signaling: role of localized akt activation and compartment-specific target proteins for the cellular radiation response. Cancers. 2018;10(3):78. ID - ref54 ER - TY - JOUR AU - Henderson, V. AU - Smith, B. AU - Burton, L. J. AU - Randle, D. AU - Morris, M. AU - Odero-Marah, V. A. PY - 2015 DA - 2015// TI - Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression JO - Cell Adhes Migr VL - 9 UR - https://doi.org/10.1080/19336918.2015.1013383 DO - 10.1080/19336918.2015.1013383 ID - Henderson2015 ER - TY - JOUR AU - Arteaga, C. L. PY - 2010 DA - 2010// TI - Clinical development of phosphatidylinositol-3 kinase pathway inhibitors JO - Curr Top Microbiol Immunol VL - 347 ID - Arteaga2010 ER - TY - JOUR AU - Shaw, R. AU - Festing, M. F. AU - Peers, I. AU - Furlong, L. PY - 2002 DA - 2002// TI - Use of factorial designs to optimize animal experiments and reduce animal use JO - ILAR J VL - 43 UR - https://doi.org/10.1093/ilar.43.4.223 DO - 10.1093/ilar.43.4.223 ID - Shaw2002 ER - TY - JOUR AU - Yang, J. AU - Nie, J. AU - Ma, X. AU - Wei, Y. AU - Peng, Y. AU - Wei, X. PY - 2019 DA - 2019// TI - Targeting PI3K in cancer: mechanisms and advances in clinical trials JO - Mol Cancer VL - 18 UR - https://doi.org/10.1186/s12943-019-0954-x DO - 10.1186/s12943-019-0954-x ID - Yang2019 ER - TY - JOUR AU - Calvo, E. AU - Bolos, V. AU - Grande, E. PY - 2009 DA - 2009// TI - Multiple roles and therapeutic implications of Akt signaling in cancer JO - OncoTargets Therap VL - 2 ID - Calvo2009 ER - TY - JOUR AU - Yin, Y. AU - Sui, C. AU - Meng, F. AU - Ma, P. AU - Jiang, Y. PY - 2017 DA - 2017// TI - The omega-3 polyunsaturated fatty acid docosahexaenoic acid inhibits proliferation and progression of non-small cell lung cancer cells through the reactive oxygen species-mediated inactivation of the PI3K /Akt pathway JO - Lipids Health Dis VL - 16 UR - https://doi.org/10.1186/s12944-017-0474-x DO - 10.1186/s12944-017-0474-x ID - Yin2017 ER - TY - JOUR AU - Shin, S. AU - Jing, K. AU - Jeong, S. AU - Kim, N. AU - Song, K. S. AU - Heo, J. Y. AU - Park, H. AU - SeoK, S. AU - Han, J. AU - Park, J. AU - Kweon, G. R. AU - Kiel Park, S. AU - Wu, T. AU - Hwang, B. D. AU - Lim, K. PY - 2013 DA - 2013// TI - The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53 JO - BioMed Res Int VL - 2013 UR - https://doi.org/10.1155/2013/568671 DO - 10.1155/2013/568671 ID - Shin2013 ER - TY - JOUR AU - Huang, L. H. AU - Chung, H. Y. AU - Su, H. M. PY - 2017 DA - 2017// TI - Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line JO - BMC Cancer VL - 17 UR - https://doi.org/10.1186/s12885-017-3936-7 DO - 10.1186/s12885-017-3936-7 ID - Huang2017 ER - TY - JOUR AU - Pardoll, D. M. PY - 2012 DA - 2012// TI - The blockade of immune checkpoints in cancer immunotherapy JO - Nat Rev Cancer VL - 12 UR - https://doi.org/10.1038/nrc3239 DO - 10.1038/nrc3239 ID - Pardoll2012 ER - TY - JOUR AU - Sun, C. AU - Mezzadra, R. AU - Schumacher, T. N. PY - 2018 DA - 2018// TI - Regulation and function of the PD-L1 checkpoint JO - Immunity. VL - 48 UR - https://doi.org/10.1016/j.immuni.2018.03.014 DO - 10.1016/j.immuni.2018.03.014 ID - Sun2018 ER - TY - JOUR AU - Goldberg, M. V. AU - Maris, C. H. AU - Hipkiss, E. L. AU - Flies, A. S. AU - Zhen, L. AU - Tuder, R. M. AU - Grosso, J. F. AU - Harris, T. J. AU - Getnet, D. AU - Whartenby, K. A. AU - Brockstedt, D. G. AU - Dubensky, T. W. AU - Chen, L. AU - Pardoll, D. M. AU - Drake, C. G. PY - 2007 DA - 2007// TI - Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells JO - Blood. VL - 110 UR - https://doi.org/10.1182/blood-2006-12-062422 DO - 10.1182/blood-2006-12-062422 ID - Goldberg2007 ER - TY - JOUR AU - Zha, Y. AU - Blank, C. AU - Gajewski, T. F. PY - 2004 DA - 2004// TI - Negative regulation of T-cell function by PD-1 JO - Crit Rev Immunol VL - 24 UR - https://doi.org/10.1615/CritRevImmunol.v24.i4.10 DO - 10.1615/CritRevImmunol.v24.i4.10 ID - Zha2004 ER - TY - JOUR AU - Zerdes, I. AU - Matikas, A. AU - Bergh, J. AU - Rassidakis, G. Z. AU - Foukakis, T. PY - 2018 DA - 2018// TI - Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations JO - Oncogene. VL - 37 UR - https://doi.org/10.1038/s41388-018-0303-3 DO - 10.1038/s41388-018-0303-3 ID - Zerdes2018 ER - TY - STD TI - Lastwika KJ, Wilson W, 3rd, Li QK, Norris J, Xu H, Ghazarian SR, Kitagawa H, Kawabata S, Taube JM,Yao S, Liu Ln, Gills JJ,Dennis PA. Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. Cancer Res 2016;76(2):227–238. ID - ref68 ER - TY - JOUR AU - Bai, J. AU - Gao, Z. AU - Li, X. AU - Dong, L. AU - Han, W. AU - Nie, J. PY - 2017 DA - 2017// TI - Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade JO - Oncotarget. VL - 8 UR - https://doi.org/10.18632/oncotarget.22690 DO - 10.18632/oncotarget.22690 ID - Bai2017 ER - TY - JOUR AU - Sumimoto, H. AU - Takano, A. AU - Teramoto, K. AU - Daigo, Y. PY - 2016 DA - 2016// TI - RAS-mitogen-activated protein kinase signal is required for enhanced PD-L1 expression in human lung cancers JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0166626 DO - 10.1371/journal.pone.0166626 ID - Sumimoto2016 ER - TY - JOUR AU - Liang, H. AU - Liu, X. AU - Wang, M. PY - 2018 DA - 2018// TI - Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment JO - Onco Targets Ther VL - 11 UR - https://doi.org/10.2147/OTT.S178497 DO - 10.2147/OTT.S178497 ID - Liang2018 ER - TY - JOUR AU - Zhang, N. AU - Zeng, Y. AU - Du, W. AU - Zhu, J. AU - Shen, D. AU - Liu, Z. PY - 2016 DA - 2016// TI - Huang JA. The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer JO - Int J Oncol VL - 49 UR - https://doi.org/10.3892/ijo.2016.3632 DO - 10.3892/ijo.2016.3632 ID - Zhang2016 ER - TY - JOUR AU - Sasada, T. AU - Azuma, K. AU - Ohtake, J. AU - Fujimoto, Y. PY - 2016 DA - 2016// TI - Immune responses to epidermal growth factor receptor (EGFR) and their application for Cancer treatment JO - Front Pharmacol VL - 7 UR - https://doi.org/10.3389/fphar.2016.00405 DO - 10.3389/fphar.2016.00405 ID - Sasada2016 ER - TY - JOUR AU - Yin, X. AU - Wang, Y. AU - Bai, S. AU - Feng, W. AU - Feng, L. AU - Zhao, W. AU - Wei, M. AU - Pang, X. AU - Liu, S. AU - Chen, H. AU - He, F. AU - Cheng, Y. AU - Yin, J. AU - Zhang, D. AU - Zheng, J. AU - Wang, L. AU - Fan, X. AU - Wan, X. PY - 2019 DA - 2019// TI - Epidermal growth factor receptor stabilizes programmed death ligand 1 by glycosylation in colorectal cancer with microstatellite instability status JO - J Bio-X Research VL - 2 ID - Yin2019 ER - TY - JOUR AU - Chen, N. AU - Fang, W. AU - Zhan, J. AU - Hong, S. AU - Tang, Y. AU - Kang, S. AU - Zhang, Y. AU - He, X. AU - Zhou, T. AU - Qin, T. AU - Huang, Y. AU - Yi, X. AU - Zhang, L. PY - 2015 DA - 2015// TI - Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-driven NSCLC: implication for optional immune targeted therapy for NSCLC patients with EGFR mutation JO - J Thorac Oncol VL - 10 UR - https://doi.org/10.1097/JTO.0000000000000500 DO - 10.1097/JTO.0000000000000500 ID - Chen2015 ER - TY - JOUR AU - Chen, H. -. N. AU - Liang, K. -. H. AU - Lai, J. -. K. AU - Lan, C. -. H. AU - Liao, M. -. Y. AU - Hung, S. -. H. AU - Chuang, Y. -. T. AU - Chen, K. -. C. AU - Wei-FuW, T. AU - Wu, H. C. PY - 2020 DA - 2020// TI - EpCAM signaling promotes tumor progression and protein stability of PD-L1 through the EGFR pathway JO - Cancer Res VL - 80 UR - https://doi.org/10.1158/0008-5472.CAN-20-1264 DO - 10.1158/0008-5472.CAN-20-1264 ID - Chen2020 ER - TY - JOUR AU - Fang, W. AU - Zhang, J. AU - Hong, S. AU - Zhan, J. AU - Chen, N. AU - Qin, T. AU - Tang, Y. AU - Zhang, Y. AU - Kang, S. AU - Zhou, T. AU - Wu, X. AU - Liang, W. AU - Hu, Z. AU - Ma, Y. AU - Zhao, Y. AU - Tian, Y. AU - Yang, Y. AU - Xue, C. AU - Yan, Y. AU - Hou, X. AU - Huang, P. AU - Huang, Y. AU - Zhao, H. AU - Zhang, L. PY - 2014 DA - 2014// TI - EBV-driven LMP1 and IFN-gamma up-regulate PD-L1 in nasopharyngeal carcinoma: implications for oncotargeted therapy JO - Oncotarget VL - 5 UR - https://doi.org/10.18632/oncotarget.2608 DO - 10.18632/oncotarget.2608 ID - Fang2014 ER -