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Table 5 Minimal inhibitory concentrations of tested samples in presence of PAβN

From: Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide

Bacterial strains

Tested samples and concentrations (μg/mL)

CSB

CSBc

CSBc1

CSBc2

CSBc3

Chloramphenicol

MIC

+PAβN

R

MIC

+PAβN

R

MIC

+PAβN

R

MIC

+PAβN

R

MIC

+PAβN

R

MIC

+PAβN

R

Escherichia coli

 ATCC8739

512

64

8

512

16

32

256

16

16

256

64

4

256

256

1

2

< 0,5

> 4

 AG102

512

64

8

512

32

16

nd

256

< 4

> 64

64

> 8

32

4

8

Klebsiella pneumoniae

 ATCC11296

512

< 1

512

128

4

64

16

4

256

128

2

< 4

> 128

32

8

4

 KP55

128

< 4

> 32

128

256

0.5

nd

256

> 2

nd

64

32

2

Enterobacter aerogenes

 ATCC13048

512

16

32

512

256

2

512

< 1

256

32

8

< 4

> 128

16

32

2

 EA27

32

> 16

< 4

128

64

> 8

256

> 2

nd

32

16

2

Providencia stuartii

 ATCC29916

512

32

16

512

256

2

nd

256

128

2

256

8

32

64

8

8

 PS2636

512

32

16

512

128

4

nd

256

< 2

nd

64

16

4

Pseudomonas aeruginosa

 PA01

512

nd

512

< 1

nd

nd

< 4

> 128

64

8

8

 PA124

512

nd

512

256

2

nd

128

256

0,5

16

> 32

256

16

16

PIA (%)

 

70

  

80

  

30

  

70

  

60

  

100

 
  1. MIC minimal inhibitory concentration R = AIF: MICample alone / MICample+PAβN ratio (this means the factor which determine the improvement of the activity of samples by PAβN; the activity of a sample was considered to be improved when its AIF was > 2). (+ PAβN): represent MIC values of tested samples obtained in presence of PAβN (−): MIC > 512 μg/mL for crude extract, fractions and sub-fractions PIA: percentage of improved activity nd: not determined (as no MIC values were not observed till 512 μg/mL) CSB: crude extract CSBc: fraction CSBc1, CSBc2 and CSBc3 are sub-fractions from fraction CSBc