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Table 4 Minimal inhibitory and bactericidal concentrations of different compounds

From: Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide

Bacterial strains

Compounds and concentrations (μg/mL)

1

2

6

Chloramphenicol

MIC

MBC

R

MIC

MBC

R

MIC

MBC

R

MIC

MBC

R

Escherichia coli

 ATCC8739

128

512

4

256

> 1

256

> 2

2

64

32

 AG102

256

> 1

nt

nd

nt

nd

32

256

8

Klebsiella pneumoniae

 ATCC11296

128

nt

nd

256

512

2

nt

nd

32

256

8

 KP55

> 1

512

> 1

nt

nd

64

256

4

Enterobacter aerogenes

 ATCC13048

128

> 1

nt

nd

nt

nd

16

128

8

 EA27

128

512

4

nt

nd

nt

nd

32

256

8

Providencia stuartii

 ATCC29916

128

> 1

256

> 2

nt

nd

64

256

4

 PS2636

nt

nd

nt

nd

nt

nd

64

256

4

Pseudomonas aeruginosa

 PA01

512

> 1

512

> 1

512

nt

nd

64

> 4

 PA124

nt

nd

512

> 1

nt

nd

64

> 4

 PSBS (%)

70

  

60

  

20

  

100

  
  1. MIC minimal inhibitory concentration, MBC minimal bactericidal concentration R: MBC / MIC ratio (a sample is considered as bacteriostatic or bactericidal when this ratio is > 4 or ≤ 4 respectively) (−): MIC or MBC > 512 μg/mL nt: not tested nd: not determined (as no MIC and MBC values were not observed till 512 μg/mL) PBSS: percentage of susceptible bacteria to substances Compounds 1, 2 and 6 were obtained from fraction CSBc Compounds 3 isolated from the residual extract and compounds 4 and 5 isolated from fraction CSBb did not showed any activity against all studied bacterial