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Table 2 Binding site of LF triterpenoids in CDK2 and CDK6

From: Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications

Skeleton Compounds Binding site in CDK2 Binding site in CDK6
Lupane-type LF01 hinge residues, catalytic loop catalytic loop
LF04 hinge residues catalytic loop, activation segment
LF08   catalytic loop, activation segment
LF09 K of K/E/D/D catalytic loop
LFa hinge residues, K of K/E/D/D catalytic loop
Oleanane-type LF02 K of K/E/D/D catalytic loop
LF03 hinge residues, K of K/E/D/D catalytic loop
LF05 hinge residues, catalytic loop, activation segment catalytic loop
LF07 hinge residues catalytic loop
LF10 hinge residues catalytic loop, activation segment
LF11 hinge residues catalytic loop, activation segment
LF12 hinge residues, K of K/E/D/D catalytic loop
LF13 hinge residues, K of K/E/D/D catalytic loop
LFb hinge residues, K of K/E/D/D, catalytic loop catalytic loop
LFc hinge residues, K of K/E/D/D, catalytic loop  
LFd   catalytic loop
LFe catalytic loop, activation segment activation segment
LFf K of K/E/D/D, catalytic loop activation segment
Ursane-type LF06   activation segment
LFg hinge residues, K of K/E/D/D catalytic loop
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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