Skip to main content

Table 2 Binding site of LF triterpenoids in CDK2 and CDK6

From: Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications

Skeleton

Compounds

Binding site in CDK2

Binding site in CDK6

Lupane-type

LF01

hinge residues, catalytic loop

catalytic loop

LF04

hinge residues

catalytic loop, activation segment

LF08

 

catalytic loop, activation segment

LF09

K of K/E/D/D

catalytic loop

LFa

hinge residues, K of K/E/D/D

catalytic loop

Oleanane-type

LF02

K of K/E/D/D

catalytic loop

LF03

hinge residues, K of K/E/D/D

catalytic loop

LF05

hinge residues, catalytic loop, activation segment

catalytic loop

LF07

hinge residues

catalytic loop

LF10

hinge residues

catalytic loop, activation segment

LF11

hinge residues

catalytic loop, activation segment

LF12

hinge residues, K of K/E/D/D

catalytic loop

LF13

hinge residues, K of K/E/D/D

catalytic loop

LFb

hinge residues, K of K/E/D/D, catalytic loop

catalytic loop

LFc

hinge residues, K of K/E/D/D, catalytic loop

 

LFd

 

catalytic loop

LFe

catalytic loop, activation segment

activation segment

LFf

K of K/E/D/D, catalytic loop

activation segment

Ursane-type

LF06

 

activation segment

LFg

hinge residues, K of K/E/D/D

catalytic loop