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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications

Fig. 5

Binding sites of LF triterpenoids on PTP1B and SHP2. a LF12 could bind with PTP1B at Arg221 on A site, and Asp48 on C site; b LFa could bind with PTP1B at Gln266 on A site, Tyr46 and Asp48 on C site, and Lys116 on D site; c LF03 could bind with SHP2 at Cys459 and Arg465 in P-loop; d LF04 could bind with SHP2 at Gly427 in WPD loop, and Tyr279 in pTyr recognition loop

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