Fig. 4

Binding interaction between LF01 and ErbB4. a Molecular surface of the ATP binding pocket of ErBb4, colored by lipophilicity: green for hydrophobic, white for neutral and purple for hydrophilic regions. b Electrostatic map of Lys751 in the catalytic domain of ErbB4. Electrostatically preferred locations of hydrogen bond acceptor are colored red. c Electrostatic map of LF01. Electrostatically preferred locations of hydrogen bond donor are colored blue. d The 17-carboxyl group of LF01 could form hydrogen bond with Lys751 in the binding site of ErbB4