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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Jianpi Yangwei decoction promotes apoptosis and suppresses proliferation of 5-fluorouracil resistant gastric cancer cells in vitro and in vivo

Fig. 6

Immunohistochemical staining of BGC823/5-Fu tumors (Magnification 200×). Immunohistochemical staining of BGC823/5-Fu tumors was performed after the mice were treated for 14 days. As shown in the bar chart: Compared with the control group, the levels of ABCG2, MDR1 and MRP1 in JPYW-high group were significantly decreased, while the levels of Bcl-2, Caspase 3 were significantly increased (P < 0.05). Compared with the JPYW-high group, JPYW+ 5-Fu treatment significantly inhibited the expression of ABCG2, MDR1 and MRP1, while increased Bcl-2, Caspase 3 (P < 0.05). However, AKT and p-AKT didn’t show significantly difference between each group (P > 0.05)

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