Fig. 3

Effect of HESAE on the viability and LDH release in PC-12 cells treated with high-dose corticosterone. Cell viability and LDH release were evaluated by (a) MTT assay and (b) LDH assay following pre-treatment with HESAE for 48 h and high-dose corticosterone of 400 μM for 24 h. Data are expressed as mean ± SD and statistically analysed by Games-Howell’s or Tukey’s test. Asterisks (*) and hash signs (#) indicate significant differences (p < 0.05) in the viability and LDH release compared to the corticosterone group and desipramine group, respectively