Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats

Table 2 Effect of TC on cardiac TBARS level and antioxidant profile in ISO induced rats

Treatment	SOD units/min/mg protein	GSH nm/ g tissue	GPx nm/min/mg protein	TBARS nm/ g protein
Normal Control	9.48 ± 1.32	1.59 ± 0.30	17.17 ± 2.77	45.41 ± 3.75
Isoproterenol (120 mg/kg)	2.72 ± 0.40^##	0.60 ± 0.10^##	6.14 ± 0.64^##	95.69 ± 8.54^##
Vitamin E (100 mg/kg)	9.95 ± 1.91**	1.68 ± 0.12**	15.85 ± 0.86**	50.49 ± 3.41**
Low dose TC (50 mg/kg)	8.58 ± 1.42*	1.47 ± 0.21*	12.51 ± 1.19*	59.13 ± 2.80**
High Dose TC (100 mg/kg)	9.24 ± 0.94**	1.66 ± 0.04**	14.09 ± 0.81**	52.64 ± 2.73**
Drug Control TC (100 mg/kg)	6.93 ± 0.58	1.23 ± 0.16	13.71 ± 1.30	38.43 ± 1.78

The results are expressed as mean ± SEM (n = 6/group); mean differences between the groups was analyzed using one-way ANOVA with Tukey test for multiple comparison # and ## denotes p < 0.05 and p < 0.01, respectively, when compared with normal control group *and** denotes p < 0.05 and p < 0.01, respectively, when compared to isoproterenol group. p ≤ 0.05 is considered as statistically significant. Biostatistical analysis was performed using GraphPad Prism 5.0 Version

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