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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress

Fig. 6

Effect of AC extract on kinases activity of BDNF downstream in OVX rats with CUMS exposure. a The levels of phospho-Erk, phospho-Akt, and phospho-CREB in hippocampus of rats were measured after AC extract treatment. AC extract administration restored Erk, Akt, and CREB phosphorylation in OVX rats with CUMS exposure. Western blots show phosphorylation levels of Erk, Akt, and CREB in hippocampus of rats. b, c, d Quantification of phospho-proteins shown in (a). The relative levels of phospho-proteins were normalized to total protein levels. The band intensities were measured using Image J. N = 3 independent ELISA from 5 rats for each experimental group. Data represent mean ± SEM. Statistical significance was determined by multiple t-test with Bonferonni correction test. *P < 0.05, **P < 0.01, ***P < 0.001

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