Fig. 3

Effect of AC extract on depression-like behaviors in OVX rats with CUMS exposure. a, b The depression-like behavior of rats during FST. The time of immobility (b) and the time of swimming (b). AC extract administration decreased immobility times and increased swimming times in OVX rats with CUMS exposure. N = 12 rats for each experimental group. Data represent mean ± SEM. Statistical significance was determined by multiple t-test with Bonferonni correction test. *P < 0.05, **P < 0.01, ***P < 0.001. c The depression-like behavior of rats during EPM. d, e Quantification of (c). The spend time of open arm (d) and the spend time of closed arm (e). AC extract administration increased open arm spent times and decreased close arm spent times in OVX rats with CUMS exposure. N = 12 rats for each experimental group. Data represent mean ± SEM. Statistical significance was determined by multiple t-test with Bonferonni correction test. *P < 0.05, **P < 0.01, ***P < 0.001