Table 5 IC50 values of xanthine oxidase inhibition of compounds 1 and 2 compared to allopurinol
Compound | Concentration (μg/mL) | Percentage of xanthine oxidase inhibition (%) | IC50 value of xanthine oxidase inhibition (μg/mL)a |
|---|---|---|---|
1 | 0.39 | 39.57 ± 0.68 | 0.66 ± 0.01 b |
0.78 | 54.14 ± 0.34 | ||
1.56 | 66.49 ± 0.05 | ||
3.13 | 76.17 ± 0.52 | ||
6.25 | 86.02 ± 0.14 | ||
12.5 | 91.75 ± 0.22 | ||
25 | 95.04 ± 0.86 | ||
50 | 96.91 ± 0.06 | ||
100 | 98.46 ± 0.37 | ||
2 | 6.25 | 9.11 ± 0.28 | 31.2 ± 1.28 |
12.5 | 14.54 ± 0.45 | ||
25 | 36.31 ± 0.08 | ||
50 | 74.08 ± 0.50 | ||
100 | 91.54 ± 0.08 | ||
Allopurinol (positive control) | 0.0064 | 4.12 ± 0.00 | 0.24 ± 0.00 |
0.032 | 17.81 ± 0.00 | ||
0.16 | 29.47 ± 0.00 | ||
0.8 | 93.66 ± 0.00 | ||
4 | 98.86 ± 0.00 | ||
20 | 99.01 ± 0.00 | ||
100 | 99.82 ± 0.00 |