Fig. 4

OSC-PLS-DA analysis of NMR data from the five groups of RAW 264.7 cells. a Score plot., in which Component 1 (58.7%) and component 2 (13.8%) explained 72.5% of total variance in the five groups of RAW 264.7 sample extracts, indicated the discriminations among the five groups. b, c Color-coded loadings plots. Color bar was applied, with red and blue representing metabolites that significantly or indistinctively contributed to the separation of groups, respectively. Peaks in positive and negative status reveal decreased and increased metabolites, respectively, relative to the score plot in the 3-CT-treated group. d S-plot indicated the metabolites responsible for the significantly discrimination among these groups