TY - JOUR AU - Meyer, J. S. AU - Xu, G. AU - Thornby, J. AU - Chowdhury, M. H. AU - Quach, M. PY - 2002 DA - 2002// TI - Is mild cognitive impairment prodromal for vascular dementia like Alzheimer’s disease? JO - Stroke VL - 33 UR - https://doi.org/10.1161/01.STR.0000024432.34557.10 DO - 10.1161/01.STR.0000024432.34557.10 ID - Meyer2002 ER - TY - JOUR AU - Langa, K. M. AU - Levine, D. A. PY - 2014 DA - 2014// TI - The diagnosis and management of mild cognitive impairment: a clinical review JO - JAMA VL - 312 UR - https://doi.org/10.1001/jama.2014.13806 DO - 10.1001/jama.2014.13806 ID - Langa2014 ER - TY - JOUR AU - Gauthier, S. AU - Reisberg, B. AU - Zaudig, M. AU - Petersen, R. C. AU - Ritchie, K. AU - Broich, K. AU - Belleville, S. AU - Brodaty, H. PY - 2006 DA - 2006// TI - Mild cognitive impairment JO - Lancet VL - 367 UR - https://doi.org/10.1016/S0140-6736(06)68542-5 DO - 10.1016/S0140-6736(06)68542-5 ID - Gauthier2006 ER - TY - JOUR AU - Petersen, R. C. PY - 2011 DA - 2011// TI - Mild cognitive impairment JO - N Engl J Med VL - 364 UR - https://doi.org/10.1056/NEJMcp0910237 DO - 10.1056/NEJMcp0910237 ID - Petersen2011 ER - TY - JOUR AU - Hugo, J. AU - Ganguli, M. PY - 2014 DA - 2014// TI - Dementia and cognitive impairment: epidemiology, diagnosis, and treatment JO - Clin Geriatr Med VL - 30 UR - https://doi.org/10.1016/j.cger.2014.04.001 DO - 10.1016/j.cger.2014.04.001 ID - Hugo2014 ER - TY - JOUR AU - Masters, C. L. AU - Bateman, R. AU - Blennow, K. AU - Rowe, C. C. AU - Sperling, R. A. AU - Cummings, J. L. PY - 2015 DA - 2015// TI - Alzheimer's disease JO - Nat Rev Dis Primers VL - 1 UR - https://doi.org/10.1038/nrdp.2015.56 DO - 10.1038/nrdp.2015.56 ID - Masters2015 ER - TY - JOUR AU - Scarpini, E. AU - Schelterns, P. AU - Feldman, H. PY - 2003 DA - 2003// TI - Treatment of Alzheimer's disease; current status and new perspectives JO - Lancet Neurol VL - 2 UR - https://doi.org/10.1016/S1474-4422(03)00502-7 DO - 10.1016/S1474-4422(03)00502-7 ID - Scarpini2003 ER - TY - JOUR PY - 2018 DA - 2018// TI - 2018 Alzheimer's disease facts and figures JO - Alzheimers Dement VL - 14 UR - https://doi.org/10.1016/j.jalz.2018.02.001 DO - 10.1016/j.jalz.2018.02.001 ID - ref8 ER - TY - JOUR AU - Angelucci, F. AU - Spalletta, G. AU - Iulio, F. AU - Ciaramella, A. AU - Salani, F. AU - Colantoni, L. AU - Varsi, A. E. AU - Giann, W. AU - Sancesario, G. AU - Caltagirone, C. AU - Bossu, P. PY - 2010 DA - 2010// TI - Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients are characterized by increased BDNF serum levels JO - Curr Alzheimer Res VL - 7 UR - https://doi.org/10.2174/156720510790274473 DO - 10.2174/156720510790274473 ID - Angelucci2010 ER - TY - STD TI - Alzheimer’s Association. FDA-Approved Treatment for Alzheimer’s. https://alz.org/media/Documents/fda-approved-treatments-alzheimers-ts.pdf. Accessed March 2019. UR - https://alz.org/media/Documents/fda-approved-treatments-alzheimers-ts.pdf ID - ref10 ER - TY - JOUR AU - Livingston, G. AU - Sommerlad, A. AU - Orgeta, V. AU - Costafreda, S. G. AU - Huntley, J. AU - Ames, D. AU - Ballard, C. AU - Banerjee, S. AU - Burns, A. AU - Cohen-Mansfield, J. AU - Cooper, C. AU - Fox, N. AU - Giltin, L. N. AU - Howard, R. PY - 2017 DA - 2017// TI - Dementia prevention, intervention, and care JO - Lancet VL - 390 UR - https://doi.org/10.1016/S0140-6736(17)31363-6 DO - 10.1016/S0140-6736(17)31363-6 ID - Livingston2017 ER - TY - JOUR AU - Javadi, B. AU - Sahebkar, A. AU - Emami, S. A. PY - 2013 DA - 2013// TI - A survey on saffron in major Islamic traditional medicine books JO - Iran J Basic Med Sci VL - 16 ID - Javadi2013 ER - TY - JOUR AU - Hajiaghaee, R. AU - Akhondzadeh, S. PY - 2012 DA - 2012// TI - Herbal medicine in the treatment of Alzheimer’s disease JO - J Med Plants VL - 1 ID - Hajiaghaee2012 ER - TY - JOUR AU - Howes, M. -. J. R. AU - Fang, R. AU - Houghton, P. J. PY - 2017 DA - 2017// TI - Effect of Chinese herbal medicine on Alzheimer's disease JO - Int Rev Neurobiol VL - 135 UR - https://doi.org/10.1016/bs.irn.2017.02.003 DO - 10.1016/bs.irn.2017.02.003 ID - Howes2017 ER - TY - JOUR AU - Rahimi, R. AU - Irannejad, S. AU - Noroozian, M. PY - 2017 DA - 2017// TI - Avicenna’s pharmacological approach to memory enhancement JO - Neurol Sci VL - 38 UR - https://doi.org/10.1007/s10072-017-2835-7 DO - 10.1007/s10072-017-2835-7 ID - Rahimi2017 ER - TY - JOUR AU - Akhondzadeh, S. AU - Sabet, M. S. AU - Harirchian, M. H. AU - Togha, M. AU - Cheraghmakani, H. AU - Razeghi, S. AU - Hejazi, S. S. AU - Yousefi, M. H. AU - Alimardani, R. AU - Jamshidi, A. AU - Rezazadeh, S. A. AU - Yousefi, A. AU - Zare, F. AU - Moradi, A. AU - Vossoughi, A. PY - 2010 DA - 2010// TI - A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease JO - Psychopharmacology VL - 207 UR - https://doi.org/10.1007/s00213-009-1706-1 DO - 10.1007/s00213-009-1706-1 ID - Akhondzadeh2010 ER - TY - JOUR AU - Akhondzadeh, S. AU - Sabet, M. S. AU - Harirchian, M. H. AU - Togha, M. AU - Cheraghmakani, H. AU - Razeghi, S. AU - Hejazi, S. S. AU - Yousefi, M. H. AU - Alimardani, R. AU - Jamshidi, A. AU - Zare, F. AU - Moradi, A. PY - 2010 DA - 2010// TI - Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial JO - J Clin Pharm Ther VL - 35 UR - https://doi.org/10.1111/j.1365-2710.2009.01133.x DO - 10.1111/j.1365-2710.2009.01133.x ID - Akhondzadeh2010 ER - TY - JOUR AU - Farokhnia, M. AU - Shafiee Sabet, M. AU - Iranpour, N. AU - Gougol, A. AU - Yekehtaz, H. AU - Alimardani, R. AU - Farsad, F. AU - Kamalipour, M. AU - Akhondzadeh, S. PY - 2014 DA - 2014// TI - Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial JO - Hum Psychopharmacol VL - 29 UR - https://doi.org/10.1002/hup.2412 DO - 10.1002/hup.2412 ID - Farokhnia2014 ER - TY - JOUR AU - Tsolaki, M. AU - Karathanasi, E. AU - Lazarou, I. AU - Dovas, K. AU - Verykouki, E. AU - Karacostas, A. AU - Georgiadis, K. AU - Tsolaki, A. AU - Adam, K. AU - Kompatsiaris, I. AU - Sinakos, Z. PY - 2016 DA - 2016// TI - Efficacy and safety of crocus sativus L. in patients with mild cognitive impairment: one year single-blind randomized, with parallel groups, clinical trial JO - J Alzheimers Dis VL - 54 UR - https://doi.org/10.3233/JAD-160304 DO - 10.3233/JAD-160304 ID - Tsolaki2016 ER - TY - STD TI - Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of alzheimer’s disease. Antioxidants. 2016;5(4):40. https://doi.org/10.3390/antiox5040040. ID - ref20 ER - TY - JOUR AU - Akram, M. AU - Nawaz, A. PY - 2017 DA - 2017// TI - Effects of medicinal plants on alzheimer’s disease and memory deficits JO - Neural Regen Res VL - 12 UR - https://doi.org/10.4103/1673-5374.205108 DO - 10.4103/1673-5374.205108 ID - Akram2017 ER - TY - JOUR AU - Berger, F. AU - Hensel, A. AU - Nieber, K. PY - 2012 DA - 2012// TI - Crocus sativus L. is not just a spice: Neuroprotective effect of saffron extract JO - Z Phytother VL - 33 UR - https://doi.org/10.1055/s-0032-1309284 DO - 10.1055/s-0032-1309284 ID - Berger2012 ER - TY - STD TI - Chang D, Liu J, Bilinski K, Xu L, Steiner GZ, Seto SW, Bensoussan A. Herbal medicine for the treatment of vascular dementia: An overview of scientific evidence. Evidence-based Complementary and Alternative Medicine. 2016: article number 7293626, 2016. ID - ref23 ER - TY - JOUR AU - Christodoulou, E. AU - Kadoglou, N. P. AU - Kostomitsopoulos, N. AU - Valsami, G. PY - 2015 DA - 2015// TI - Saffron: a natural product with potential pharmaceutical applications JO - J Pharm Pharmacol VL - 67 UR - https://doi.org/10.1111/jphp.12456 DO - 10.1111/jphp.12456 ID - Christodoulou2015 ER - TY - JOUR AU - Cicero, A. F. G. AU - Fogacci, F. AU - Banach, M. PY - 2018 DA - 2018// TI - Botanicals and phytochemicals active on cognitive decline: the clinical evidence JO - Pharmacol Res VL - 130 UR - https://doi.org/10.1016/j.phrs.2017.12.029 DO - 10.1016/j.phrs.2017.12.029 ID - Cicero2018 ER - TY - JOUR AU - Finley, J. W. AU - Gao, S. PY - 2017 DA - 2017// TI - A perspective on Crocus sativus L. (saffron) constituent crocin: a potent water-soluble antioxidant and potential therapy for Alzheimer's disease JO - J Agric Food Chem VL - 65 UR - https://doi.org/10.1021/acs.jafc.6b04398 DO - 10.1021/acs.jafc.6b04398 ID - Finley2017 ER - TY - JOUR AU - Hajiaghaee, R. AU - Akhondzadeh, S. PY - 2012 DA - 2012// TI - Herbal medicine in the treatment of Alzheimer's disease JO - J Med Plants VL - 11 ID - Hajiaghaee2012 ER - TY - JOUR AU - Leone, S. AU - Recinella, L. AU - Chiavaroli, A. AU - Orlando, G. AU - Ferrante, C. AU - Leporini, L. PY - 2018 DA - 2018// TI - Phytotherapic use of the Crocus sativus L. (saffron) and its potential applications: a brief overview JO - Phytother Res VL - 32 UR - https://doi.org/10.1002/ptr.6181 DO - 10.1002/ptr.6181 ID - Leone2018 ER - TY - JOUR AU - Milajerdi, A. AU - Bitarafan, V. AU - Mahmoudi, M. PY - 2015 DA - 2015// TI - A review on the effects of saffron extract and its constituents on factors related to neurologic, cardiovascular and gastrointestinal diseases JO - J Med Plants VL - 14 ID - Milajerdi2015 ER - TY - JOUR AU - Mirmosayyeb, O. AU - Tanhaei, A. AU - Sohrabi, H. R. AU - Martins, R. N. AU - Tanhaei, M. AU - Najafi, M. A. PY - 2017 DA - 2017// TI - Possible role of common spices as a preventive and therapeutic agent for Alzheimer’s disease JO - Int J Prev Med VL - 8 UR - https://doi.org/10.4103/2008-7802.199640 DO - 10.4103/2008-7802.199640 ID - Mirmosayyeb2017 ER - TY - JOUR AU - Moshiri, M. AU - Vahabzadeh, M. AU - Hosseinzadeh, H. PY - 2015 DA - 2015// TI - Clinical applications of saffron (Crocus sativus) and its constituents: a review JO - Drug Res VL - 65 ID - Moshiri2015 ER - TY - STD TI - Pitsikas N. The effect of Crocus sativus L. and its constituents on memory: Basic studies and clinical applications. Evidence-based Complementary and Alternative Medicine. 2015:article number 926284, 2015. ID - ref32 ER - TY - JOUR AU - Moher, D. AU - Liberati, A. AU - Tetzlaff, J. AU - Altman, D. G. PY - 2009 DA - 2009// TI - Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement JO - PLoS Med VL - 6 UR - https://doi.org/10.1371/journal.pmed.1000097 DO - 10.1371/journal.pmed.1000097 ID - Moher2009 ER - TY - STD TI - Higgins JP, Altman DG. Assessing risk of bias in included studies. In: Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series. Volume 1. 1st edition. Edited by Higgins JP. and Green S. New Jersey: Wiley; 2008. p. 187–241. ID - ref34 ER - TY - JOUR AU - Rockwood, K. AU - Fay, S. AU - Gorman, M. AU - Carver, D. AU - Graham, J. E. PY - 2007 DA - 2007// TI - The clinical meaningfulness of ADAS-cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial JO - BMC Neurol VL - 7 UR - https://doi.org/10.1186/1471-2377-7-26 DO - 10.1186/1471-2377-7-26 ID - Rockwood2007 ER - TY - JOUR AU - Schmidt, M. AU - Betti, G. AU - Hensel, A. PY - 2007 DA - 2007// TI - Saffron in phytotherapy: pharmacology and clinical uses JO - Wien Med Wochenschr VL - 157 UR - https://doi.org/10.1007/s10354-007-0428-4 DO - 10.1007/s10354-007-0428-4 ID - Schmidt2007 ER - TY - JOUR AU - Broadhead, G. AU - Chang, A. AU - Grigg, J. AU - McCluskey, P. PY - 2016 DA - 2016// TI - Efficacy and safety of saffron supplementation: current clinical findings JO - Crit Rev Food Sci Nutr VL - 56 UR - https://doi.org/10.1080/10408398.2013.879467 DO - 10.1080/10408398.2013.879467 ID - Broadhead2016 ER - TY - JOUR AU - Bhargava, V. PY - 2011 DA - 2011// TI - Medicinal uses and pharmacological properties of Crocus sativus Linn. (Saffron) JO - Int J Pharm Pharm Sci VL - 3 ID - Bhargava2011 ER - TY - JOUR AU - Adalier, N. AU - Parker, H. PY - 2016 DA - 2016// TI - Vitamin E, turmeric and saffron in treatment of Alzheimer’s disease JO - Antioxidants VL - 5 UR - https://doi.org/10.3390/antiox5040040 DO - 10.3390/antiox5040040 ID - Adalier2016 ER - TY - JOUR AU - Khazdair, M. R. AU - Boskabady, M. H. AU - Hosseini, M. AU - Rezaee, R. AU - Tsatsakis, A. M. PY - 2015 DA - 2015// TI - The effects of Crocus sativus (saffron) and its constituents on nervous system: a review JO - Avicenna J Phytomedicine VL - 5 ID - Khazdair2015 ER -