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Table 1 Characteristics of included randomized trials of acupuncture for ulcerative colitis

From: Acupuncture for ulcerative colitis: a systematic review and meta-analysis of randomized clinical trials

Study ID Year Gender male/female Sample size Age (mean or range, yrs) Course of disease (mean or range) Course of treatment, days Intervention vs. Control Outcomes Acupuncture intervention details Control measures
Acupuncture point [25] Acupuncture on one or both sides of the body Duration of each treatment Frequency With or without conventional medicine
RenY2014 2014 I:10/14
C:12/12
I:24
C:24
I:46.25 ± 15.11
C:50.2 ± 14.19
I:5.08 ± 2.1 years
C:4.83 ± 1.74 years
46 Acupuncture + mesalazine vs. mesalazine Clinical effect, activity index for UC, TCM syndrome score, colonoscopy curative effect, mucosal pathology, adverse effects BL23, BL20, BL25, BL21, SP4, ST25, ST36, KI3, CV12, CV4 both sides 30 min 1 time/day Y mesalazine: 1 time/day, 1.0 g/time
JiaJN2015 2015 I:16/16
C:18/14
I:32
C:32
I:28–60
C:24–57
I:1–8 years
C:1–7 years
60 Acupuncture + mesalazine vs. mesalazine Clinical effect, T Cell subsets CV3, CV4, CV6, ST25, SP15, BL25, ST36, ST37, SP6, LR3 NR 30 min 1 time/day Y mesalazine: 4 times/day, 1.0 g/time
YangSQ2012 2012 I:14/16
C:15/15
I:30
C:30
I:24–49
C:25–53
I:0.5–5 years
C:0.7–6 years
28 Acupuncture + mesalazine vs. mesalazine Clinical effect, clinical symptom score, colonoscopy curative effect, self-rating depression scale, adverse effects Selected the frontal area as the therapeutic area by seven - area division of the head acupoints NR 6 h NR Y mesalazine: 4 times/day, 1.0 g/time
XueLZ2018 2018 I:25/22
C:24/23
I:47
C:47
I:28–75(40.3 ± 13.9)
C:29–74(40.1 ± 12.8)
I:NRC:NR 14 Acupuncture vs. metronidazole + sulfasalazine Clinical effect, adverse effects CV4, CV6, GV1, BL25, ST25, SP6, ST36 NR 20 min 1 time/day N metronidazole: 3 times/day, 0.2 g/time; sulfasalazine: 3 times/day,0.2 g/time
LiuXH2013 2013 I:29/33
C:30/32
I:62
C:62
I:23–76(50.67 ± 6.82)
C:24–74(51.14 ± 5.46)
I:9–19(13.63 ± 5.16) months
C:9–20(14.10 ± 5.22) months
Acupuncture vs. metronidazole + sulfasalazine Clinical effect, adverse effects CV4, CV6, ST25, BL25, GV1, ST36, SP6 NR 10 -30 min 2 times/day N metronidazole: 3 times/day, 2-3 g/time; sulfasalazine: 3 times/day, The starting dose is 2–3 g/day, which can be increased to 4–6 g/day according to the patient’s condition. After the patient’s condition is stable, the dosage can be reduced to 1.5 to 2 g/day
LiCH2017 2017 I:25/25
C:26/24
I:50
C:50
I:27–75(45.5 ± 4.5)
C:27–76(46.8 ± 4.2)
I:9–18(13 ± 1.5) months
C:10–18(12 ± 1.8) months
Acupuncture vs. metronidazole + sulfasalazine Clinical effect, pathological change ratio CV4, CV6, ST25, GV1, BL25, SP6, ST36 NR 10-30 min 2 times/day N metronidazole: 3 times/day, 0.2 g/time; sulfasalazine: 3 times/day, 2.0 g/time
ZhangZZ2018 2018 I:29/21
C:27/23
I:50
C:50
I:32–66(44.1 ± 3.2)
C:31–65(43.6 ± 3.0)
I:1–9(3.6 ± 1.5) months
C:1–8(3.5 ± 1.7) months
14 Acupuncture vs. mesalazine Clinical effect, IL-2 ST25, ST36), GV1, SP6 NR 16-22 min 1 time/day N mesalazine: 3 times/day, 1.0–2.0 g/time
WangMC2017 2017 I:12/13
C:17/8
I:25
C:25
I:38–74(56.8 ± 2.4)
C:36–69(52.5 ± 3.8)
I:1 month-4 years
C:1 month-3 years
10 Acupuncture vs. mesalazine Clinical effect, adverse effects ST25, SP6, GV1, ST36, BL18, BL20, BL23 NR 20 min 1 time/day N mesalazine: 3 times/day, 2.0 g/time
LuanBY2016 2016 I:13/12
C:14/11
I:25
C:25
I:26–42(34 ± 5.75)
C:23–42(31.28 ± 6.13)
I:NR
C:NR
56 Acupuncture vs. mesalazine Clinical effect, adverse effects SP4, KI3, ST36, CV4, ST25, BL16, BL20, BL21, BL22, BL25, GV2, GV6 NR 30 min 1 time/day N mesalazine: 4 times/day, 1.0 g/time
ZhangHC2009 2009 I:23/17
C:25/15
I:40
C:40
I:20–65(42.64 ± 6.9)
C:19–67(38.73 ± 7.5)
I:2.2–7.9(3.9 ± 2.3) years
C:2.2–7.4(4.1 ± 1.7) years
28 Acupuncture vs. sulfasalazine Clinical effect, adverse effects Gastric region was selected according to functional localization of cerebral cortex NR 5-10 min 1 time/day N sulfasalazine: 3 times/day, 2.0 g/time
YanZL2018 2018 I:25/20
C:23/22
I:50
C:50
I:25–78(42.6 ± 11.7)
C:26–77(41.3 ± 12.5)
I:NR
C:NR
14 Acupuncture + metronidazole + sulfasalazine vs. metronidazole + sulfasalazine Clinical effect ST25, BL25, GV1, CV6, CV4, ST36, SP6 NR 20 min 1 time/day Y metronidazole: 3 times/day,0.2 g/time; sulfasalazine: 3 times/day, 0.2 g/time
ZhangCY2018 2018 I:30/20
C:26/24
I:50
C:50
I:34–70(46.5 ± 0.5)
C:35–69(45.6 ± 0.01)
I:9 days-2 years (1.2 ± 0.01) years
C:10 days-3 years (2.1 ± 0.01) years
30 Acupuncture + metronidazole vs. metronidazole Clinical effect, adverse effects CV4, CV6, ST25, GV1, BL25, SP6, ST36 NR 10-30 min 2 times/day Y metronidazole: 3 times/day,0.2 g/time
PangHM2020 2020 I:16/14
C:19/11
I:30
C:30
I: 41.63 ± 12.86
C: 43.33 ± 15.51
I: 36.90 ± 20.94 months
C: 38.03 ± 18.42 months
30 Acupuncture + mesalazine vs. mesalazine Clinical effect, Baron score BL31, BL32, BL33,BL34 both sides 30 min 1time/2 days Y mesalazine: 4 times/day, 1.0 g/time