Table 2 Effect of estimates of oral herbal medicine for intrahepatic cholestasis in pregnancy in 43 included trials
Trials | Intervention/Comparison | Effect estimates (95%CI) | Pvalue |
|---|---|---|---|
1. The pruritus score of the pregnancy | |||
1.1 Herbal medicine vs. Conventional medicine | |||
Huang and Liu [34], 2004 | Yinchenhao Decoction | MD − 0.70 [− 0.93, − 0.47] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction | MD − 0.55 [− 1.07, − 0.03] | |
Subtotal (REM, I2 = 0%) | MD − 0.68 [− 0.88, − 0.47] | < 0.00001 | |
1.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
1.2.1 Herbal medicine plus SAMe versus SAMe | |||
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction | MD − 0.65 [− 1.02, − 0.28] | |
Wen et al. [44], 2014 | Self prescribed prescription | MD-1.27 [− 1.47, − 1.07] | |
Liu et al. [46], 2013 | Yinchendanshao Decoction | MD − 0.50 [− 1.16, 0.16] | |
Ding et al. [48], 2010 | Qingganhuayu Decoction | MD − 1.20 [− 1.57, − 0.83] | |
Liu et al. [70], 2019 | Wuling pill | MD − 1.02 [− 1.08, − 0.96] | |
Wang et al. [71], 2015 | Yinchen Decoction | MD − 0.70 [− 1.10, − 0.30] | |
Zhang [73], 2005 | Dangguidihuang Decoction | MD − 0.70 [− 0.86, − 0.54] | |
1.2.2 Herbal medicine plus UDCA versus UDCA | |||
Wang and Lai [42], 2011 | Yinchenlidan Decoction | MD − 0.70 [− 1.01, − 0.39] | |
Yin [53], 2015 | Bushenqingli Decoction | MD − 0.70 [− 1.13, − 0.27] | |
Deng [59], 2015 | Yinzhihuang oral liquid | MD − 0.68 [− 0.91, − 0.45] | |
Gu et al. [66], 2014 | Yinchen Decoction | MD −0.32 [− 0.54, − 0.10] | |
Subtotal (REM, I2 = 56%) | MD − 0.58 [− 0.79, − 0.36] | < 0.00001 | |
1.2.3 Herbal medicine plus UDCA plus SAMe versus UDCA plus SAMe | |||
Zhou et al. [37], 2017 | Yinchailishi Decoction | MD −0.77 [− 1.01, − 0.53] | |
Lan et al. [51], 2016 | Yinchenhao Decoction | MD − 1.68 [− 1.99, − 1.37] | |
Subtotal (REM, I2 = 95%) | MD − 1.22 [− 2.11, − 0.33] | < 0.00001 | |
1.2.4 Herbal medicine plus dexamethasone versus dexamethasone | |||
Liu et al. [38], 2015 | Yinchenlidan Decoction | MD −0.70 [− 0.88, − 0.52] | |
Zhao [41], 2011 | Qingyulidan Decoction | MD −0.68 [− 0.83, − 0.53] | |
Subtotal (FEM, I2 = 0%) | MD − 0.69 [− 0.80, − 0.57] | < 0.00001 | |
2. Maternal serum TBA | |||
2.1 Herbal medicine vs. Conventional medicine | |||
Yang [32], 2015 | Yinzhihuang oral liquid vs. UDCA | MD − 4.74 [− 6.57, − 2.91] | |
Li et al. [14], 2015 | Yinchenhao Decoction vs. UDCA+SAM | MD 1.40 [− 0.45, 3.25] | |
2.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
2.2.1 Herbal medicine plus SAMe versus SAMe | |||
Liu et al. [46], 2013 | Yinchendanshao Decoction | MD −10.66 [− 19.08, − 2.24] | |
Zhang [52], 2015 | Yinchenhao Decoction | MD −8.20 [− 10.04, − 6.36] | |
Wang et al. [71], 2015 | Yinchen Decoction | MD − 6.00 [− 8.18, − 3.82] | |
Zhang [73], 2005 | Dangguidihuang Decoction | MD −7.20 [− 9.39, − 5.01] | |
Subtotal (FEM, I2 = 0%) | MD − 7.33 [− 8.50, − 6.15] | < 0.00001 | |
2.2.2 Herbal medicine plus UDCA versusUDCA | |||
Wang X et al. [39], 2016 | Danyu Decoction | MD − 6.44 [− 9.73, − 3.15] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction | MD −4.33 [− 7.48, − 1.18] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction | MD − 3.51 [− 4.88, − 2.14] | |
Yin [53], 2015 | Bushenqingli Decoction | MD −4.45 [− 5.76, − 3.14] | |
Shu [58], 2018 | Qianyinlidan Decoction | MD −3.94 [− 4.20, − 3.68] | |
Wei [63], 2016 | Self prescribed prescription | MD −5.00 [− 6.78, − 3.22] | |
Gu et al. [66], 2014 | Yinchen Decoction | MD −4.81 [− 7.25, − 2.37] | |
Subtotal (FEM, I2 = 0%) | MD-3.99 [− 4.24, − 3.74] | < 0.00001 | |
2.2.3 Herbal medicine plus UDCA plus SAMe versus UDCA plus SAMe | |||
Wang et al. [36], 2016 | Yinzhihuang oral liquid | MD − 2.30 [− 4.18, − 0.42] | |
Zhou et al. [37], 2017 | Yinchailishi Decoction | MD − 7.08 [− 9.88, − 4.28] | |
Liu et al. [38], 2015 | Yinchenlidan Decoction | MD − 8.13 [− 9.45, − 6.81] | |
Lan et al. [51], 2016 | Yinchenhao Decoction | MD − 1.77 [− 4.30, 0.76] | |
Su et al. [60], 2015 | Lidan Decoction | MD − 3.42 [− 6.32, − 0.52] | |
Mao and He [67], 2014 | Qingganlidan Decoction | MD −24.10 [− 26.05, − 22.15] | |
Zheng [65], 2019 | Lidan Decoction | MD −6.38 [− 7.69, − 5.07] | |
Subtotal (REM, I2 = 98%) | MD − 7.62 [− 12.97, − 2.27] | 0.005 | |
2.2.4 Herbal medicine plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | |||
Zhao [41], 2011 | Qingyulidan Decoction | MD-3.57 [−4.74, − 2.40] | |
Shan et al. [50], 2016 | Huashilidan Decoction | MD-3.54 [− 5.33, − 1.75] | |
Li et al.,14 2015 | Yinchenhao Decoction | MD-5.00 [− 6.71, − 3.29] | |
Zhang et al. [57], 2016 | Self prescribed prescription | MD-3.37 [− 3.86, − 2.88] | |
Subtotal (FEM, I2 = 8%) | MD-3.50 [−3.93, − 3.08] | < 0.00001 | |
3. The number of fetal distress | |||
3.1 Herbal medicine vs. Conventional medicine | |||
Zhang [31], 2006 | Self prescribed prescription vs SAMe+Reduced glutathione | RR 0.93 [0.39,2.20] | |
Huang and Liu [34], 2004 | Yinchenhao Decoction vs SAMe | RR 0.86 [0.29, 2.50] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | RR 0.47 [0.13, 1.70] | |
Subtotal (FEM, I2 = 0%) | RR 0.77 [0.43, 1.39] | 0.39 | |
3.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Wang et al. [36], 2016 | Yinzhihuang oral liquid plus UDCA and SAMe versus UDCA and SAMe | RR 0.22 [0.05, 0.96] | |
Zhou et al. [37], 2017 | Yinchailishi Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.33 [0.01, 7.87] | |
Liu et al. [38], 2015 | Yinchenlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.31 [0.12, 0.81] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction plus UDCA versus UDCA | RR 0.39 [0.08, 1.83] | |
Zhao [41], 2011 | Qingyulidan Decoction plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | RR 0.25 [0.06, 1.13] | |
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction plus SAMe versus SAMe | RR 0.38 [0.11, 1.28] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction plus UDCA versus UDCA | RR 0.29 [0.08, 1.02] | |
Tian et al. [47], 2016 | Kangdanyu Decoction plus Reduced glutathione plus UDCA plus SAMe plus DXM versus Reduced glutathione plus UDCA plus SAMe | RR 1.40 [0.71, 2.76] | |
Zhang et al. [49], 2014 | Qingdanzhiyang Decoction plus SAMe, phenobarbital and DXM versus SAMe, phenobarbital and DXM | RR 0.27 [0.08, 0.88] | |
Shan et al. [50], 2016 | Huashilidan Decoction plusUDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | RR 0.40 [0.08, 1.96] | |
Lan et al. [51], 2016 | Yinchenhao Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.54 [0.24, 1.21] | |
Yin [53], 2015 | Bushenqingli Decoction plus UDCA versus UDCA | RR 0.33 [0.10, 1.11] | |
Su et al. [60], 2015 | Lidan Decoction plus UDCA, SAMe and Magnesium isoglycyrrhizinate versus UDCA, SAMe and Magnesium isoglycyrrhizinate | RR 0.67 [0.12, 3.76] | |
Wang et al. [62], 2018 | Yinzhihuang granule plus UDCA, SAMe and DXM versus UDCA, SAMe and DXM | RR 0.20 [0.05, 0.84] | |
Wei [63], 2016 | Self prescribed prescription plus UDCA versus UDCA | RR 0.21 [0.08, 0.55] | |
Zhang [64], 2017 | Lidan Decoction plus UDCA versus UDCA | RR 0.25 [0.03, 2.17] | |
Zheng [65], 2019 | Yinchen Decoction plus UDCA, SAMe and Phenobarbital versus UDCA, SAMe and Phenobarbital | RR 0.50 [0.05, 5.31] | |
Mao and He [67], 2014 | Qingganlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.31 [0.12, 0.80] | |
Mao [68], 2016 | Yinchenhao Decoction plus UDCA versus UDCA | RR 0.97 [0.06, 15.02] | |
Zhu and Huang [69], 2008 | Yinchenhao Decoction plus UDCA versus UDCA | RR 0.86 [0.29, 2.50] | |
Liu et al. [70], 2019 | Wuling pill plus SAMe versus SAMe | RR 0.40 [0.08, 1.98] | |
Wang et al. [71], 2015 | Yinchenhao Decoction plus SAMe versus SAMe | Not estimable | |
Du and Li [72], 2014 | Yiguanjian Decoction plus UDCA and DXM versus UDCA and DXM | RR 0.35 [0.17, 0.75] | |
Zhang [73], 2005 | Dangguidihuang Decoction plus SAMe versus SAMe | RR 0.50 [0.21, 1.20] | |
Overall (FEM, I2 = 0%) | RR0.41 [0.32, 0.51] | < 0.00001 | |
4. The number of asphyxia neonatorum | |||
4.1 Herbal medicine vs. Conventional medicine | |||
Yang [32], 2015 | Yinzhihuang oral liquid vs UDCA | RR 1.00 [0.06,16.76] | 1.00 |
4.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Zhou et al. [37], 2017 | Yinchailishi Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.33 [0.01, 7.87] | |
Wang X et al. [39], 2016 | Danyu Decoction plus UDCA versus UDCA | RR 0.33 [0.07, 1.58] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction plus UDCA versus UDCA | RR 0.48 [0.05, 5.03] | |
Zhao [41], 2011 | Qingyulidan Decoction plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | RR 0.25 [0.03, 2.17] | |
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction plus SAMe versus SAMe | RR 0.11 [0.01, 1.98] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction plus UDCA versus UDCA | RR 0.29 [0.08, 1.02] | |
Tian et al. [47], 2016 | Kangdanyu Decoction plus Reduced glutathione, UDCA, SAMe and DXM versus Reduced glutathione, UDCA and SAMe | RR 0.85 [0.43, 1.65] | |
Ding et al. [48], 2010 | Qingganhuayu Decoction plus SAMe versus SAMe | RR 0.33 [0.13, 0.88] | |
Zhang et al. [49], 2014 | Qingdanzhiyang Decoction plus SAMe, phenobarbital and DXM versus SAMe, phenobarbital and DXM | RR 0.13 [0.02, 0.94] | |
Shan et al. [50], 2016 | Huashilidan Decoction plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | RR 0.20 [0.01, 4.06] | |
Lan et al. [51], 2016 | Yinchenhao Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.50 [0.19, 1.33] | |
Zhang [52], 2015 | Yinchenhao Decoction plus SAMe versus SAMe | RR 0.25 [0.06, 1.11] | |
Yin [53], 2015 | Bushenqingli Decoction plus UDCA versus UDCA | RR 0.13 [0.02, 0.94] | |
Ma [56], 2010 | Self prescribed prescription plus UDCA versus UDCA | RR 0.38 [0.11, 1.30] | |
Wang [61], 2014 | Kangyudan Decoction plus UDCA versus UDCA | RR 0.40 [0.08, 1.93] | |
Zheng [65], 2019 | Yinchen Decoction plus UDCA, SAMe and Phenobarbital versus UDCA, SAMe and Phenobarbital | RR 0.33 [0.01, 7.96] | |
Mao and He [67], 2014 | Qingganlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.23 [0.07, 0.77] | |
Wang et al. [71], 2015 | Yinchenhao Decoction plus SAMe versus SAMe | Not estimable | |
Overall (FEM, I2 = 0%) | RR0.35 [0.25, 0.49] | < 0.00001 | |
5. The number of cesarean section | |||
5.1 Herbal medicine vs. Conventional medicine | |||
Zhang [31], 2006 | Self prescribed prescription vs SAMe and Reduced glutathione | RR 0.93 [0.56, 1.55] | |
Li et al. [14], 2015 | Yinchenhao Decoction vs. UDCA and SAM | RR 1.07 [0.85, 1.37] | |
Huang and Liu [34], 2004 | Yinchenhao Decoction vs SAMe | RR 0.93 [0.56, 1.55] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | RR 0.58 [0.22, 1.58] | |
Overall (FEM, I2 = 0%) | RR 0.97 [0.80,1.18] | 0.78 | |
5.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Wang et al. [36], 2016 | Yinzhihuang oral liquid plus UDCA and SAMe versus UDCA and SAMe | RR 0.27 [0.08, 0.90] | |
Zhou et al. [37], 2017 | Yinchailishi Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.69 [0.53, 0.90] | |
Liu et al. [38], 2015 | Yinchenlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.71 [0.51, 0.99] | |
Wang X et al. [39], 2016 | Danyu Decoction plus UDCA versus UDCA | RR 0.38 [0.23, 0.62] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction plus UDCA versus UDCA | RR 0.57 [0.32, 1.02] | |
Zhao [41], 2011 | Qingyulidan Decoction plus UDCA, SAMe and dexamethasone versus UDCA, SAMe and dexamethasone | RR 0.95 [0.73, 1.24] | |
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction plus SAMe versus SAMe | RR 0.91 [0.67, 1.24] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction plus UDCA versus UDCA | RR 0.53 [0.28, 1.00] | |
Tian et al. [47], 2016 | Kangdanyu Decoction plus Reduced glutathione, UDCA, SAMe and DXM versus Reduced glutathione, UDCA and SAMe | RR 0.52 [0.30, 0.89] | |
Ding et al. [48], 2010 | Qingganhuayu Decoction plus SAMe versus SAMe | RR 1.03 [0.89, 1.19] | |
Li et al. [14], 2015 | Yinchenhao Decoction plus UDCA andSAMe versus UDCA and SAMe | RR 0.80 [0.59, 1.08] | |
Yin [53], 2015 | Bushenqingli Decoction plus UDCA versus UDCA | RR 0.50 [0.14, 1.82] | |
Chen and Mo [55], 2005 | Self prescribed prescription plus DXM and VK3 versus DXM and VK3 | RR 1.08 [0.83, 1.39] | |
Ma [56], 2010 | Self prescribed prescription plus UDCA versus UDCA | RR 1.11 [0.72, 1.71] | |
Wang [61], 2014 | Kangyudan Decoction plus UDCA versus UDCA | RR 0.67 [0.46, 0.97] | |
Wei [63], 2016 | Self prescribed prescription plus UDCA versus UDCA | RR 0.50 [0.19, 1.29] | |
Zhang [64], 2017 | Lidan Decoction plus UDCA versus UDCA | RR 0.27 [0.08, 0.93] | |
Mao and He [67], 2014 | Qingganlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.80 [0.57, 1.13] | |
Zhu and Huang [69], 2008 | Yinchenhao Decoction plus UDCA versus UDCA | RR 0.93 [0.56, 1.55] | |
Liu et al. [70], 2019 | Wuling pill plus SAMe versus SAMe | RR 0.17 [0.02, 1.34] | |
Du and Li [72], 2014 | Yiguanjian Decoction plus UDCA and DXM versus UDCA and DXM | RR 0.39 [0.20, 0.77] | |
Zhang [73], 2005 | Dangguidihuang Decoction plus SAMe versus SAMe | RR 0.95 [0.61, 1.49] | |
Overall (REM, I2 = 65%) | RR 0.73 [0.63, 0.85] | < 0.0001 | |
6. The number of postpartum haemorrhage | |||
6.1 Herbal medicine plus versus Conventional medicine | |||
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | RR 0.47 [0.09, 2.36] | 0.36 |
6.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Wang X et al. [39], 2016 | Danyu Decoction plus UDCA versus UDCA | RR 0.50 [0.05, 5.36] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction plus UDCA versus UDCA | RR 0.48 [0.05, 5.03] | |
Zhao [41], 2011 | Qingyulidan Decoction plus UDCA, SAMe and dexamethasone versus UDCA, SAMe and dexamethasone | RR 2.00 [0.19, 21.47] | |
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction plus SAMe versus SAMe | RR 2.00 [0.19, 20.90] | |
Tian et al. [47], 2016 | Kangdanyu Decoction plus Reduced glutathione, UDCA, SAMe and DXM versus Reduced glutathione, UDCA and SAMe | RR 0.25 [0.06, 1.10] | |
Shan et al. [50], 2016 | Huashilidan Decoction plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | RR 0.50 [0.05, 5.33] | |
Yin [53], 2015 | Bushenqingli Decoction plus UDCA versus UDCA | Not estimable | |
Chen and Mo [55], 2005 | Self prescribed prescription plus DXM and VK3 versus DXM and VK3 | RR 0.67 [0.12, 3.75] | |
Su et al. [60], 2015 | Lidan Decoction plus UDCA, SAMe and Magnesium isoglycyrrhizinate versus UDCA, SAMe and Magnesium isoglycyrrhizinate | RR 0.50 [0.05, 5.28] | |
Wang [61], 2014 | Kangyudan Decoction plus UDCA versus UDCA | RR 1.00 [0.07, 15.38] | |
Zheng [65], 2019 | Yinchen Decoction plus UDCA, SAMe and Phenobarbital versus UDCA, SAMe and Phenobarbital | RR 0.33 [0.04, 3.08] | |
Mao [68], 2016 | Yinchenhao Decoction plus UDCA versus UDCA | RR 0.16 [0.02, 1.29] | |
Liu et al. [70], 2019 | Wuling pill plus SAMe versus SAMe | RR 0.40 [0.08, 1.98] | |
Du and Li [72], 2014 | Yiguanjian Decoction plus UDCA and DXM versus UDCA and DXM | RR 0.38 [0.16, 0.92] | |
Overall (FEM, I2 = 0%) | RR 0.45 [0.28, 0.72] | 0.0009 | |
7. The serum ALT values | |||
7.1 Herbal medicine vs. Conventional medicine | |||
Yang [32], 2015 | Yinzhihuang oral liquid vs. UDCA | MD − 1.54 [− 2.46, − 0.62] | |
Li et al. [14], 2015 | Yinchenhao Decoction vs. UDCA and SAM | MD 5.70 [0.50,10.90] | |
Huang and Liu [34], 2004 | Yinchenhao Decoction vs SAMe | MD 3.40 [− 12.37, 19.17] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | MD − 18.31 [− 46.10, 9.48] | |
Subtotal (REM, I2 = 67%) | MD 0.90 [− 5.10, 6.90] | 0.77 | |
7.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
7.2.1 Herbal medicine plus SAMe versus SAMe | |||
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction | MD − 11.50 [− 16.78, − 6.22] | |
Liu et al. [46], 2013 | Yinchendanshao Decoction | MD 2.97 [− 3.73, 9.67] | |
Zhang [52], 2015 | Yinchenhao Decoction | MD − 13.60 [− 19.20, − 8.00] | |
Liu et al. [70], 2019 | Wuling pill | MD − 43.86 [− 47.04, − 40.68] | |
Wang et al. [71], 2015 | Yinchenhao Decoction | MD − 10.20 [− 17.59, − 2.81] | |
Zhang [73], 2005 | Dangguidihuang Decoction plus SAMe versus SAMe | MD −14.02 [− 19.04, − 9.00] | |
7.2.2 Herbal medicine plus UDCA versus UDCA | |||
Wang X et al. [39], 2016 | Danyu Decoction | MD-26.10 [− 50.18, − 2.02] | |
Wang and Lai [42], 2011 | Yinchenlidan Decoction | MD − 72.00 [− 75.85, − 68.15] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction | MD − 13.00 [− 17.50, − 8.50] | |
Yin [53], 2015 | Bushenqingli Decoction | MD − 19.07 [− 24.70, − 13.44] | |
Shu [58], 2018 | Qianyinlidan Decoction | MD − 16.98 [− 18.89, − 15.07] | |
Deng [59], 2015 | Yinzhihuang oral liquid | MD − 10.40 [− 16.37, − 4.43] | |
Wei [63], 2016 | Self prescribed prescription | MD − 11.67 [− 17.33, − 6.01] | |
Gu et al. [66], 2014 | Yinchenhao Decoction | MD − 1.37 [− 5.07, 2.33] | |
Zhu and Huang [69], 2008 | Yinchenhao Decoction | MD − 8.60 [− 24.25, 7.05] | |
7.2.3 Herbal medicine plus UDCA and SAMe versus UDCA and SAMe | |||
Wang et al. [36], 2016 | Danyu Decoction | MD − 14.85 [− 18.88, − 10.82] | |
Li et al. [14], 2015 | Yinchenhao Decoction | MD − 21.00 [− 25.60, − 16.40] | |
Su et al. [60], 2015 | Lidan Decoction | MD − 18.40 [− 23.56, − 13.24] | |
Zheng [65], 2019 | Yinchen Decoction | MD − 19.11 [− 20.98, − 17.24] | |
Mao and He [67], 2014 | Qingganlidan Decoction | MD − 21.10 [− 24.86, − 17.34] | |
Subtotal (REM, I2 = 34%) | MD-18.94 [− 20.91, − 16.97] | < 0.0001 | |
7.2.4 Herbal medicine plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | |||
Shan et al. [50], 2016 | Huashilidan Decoction | MD-8.69 [− 13.16, − 4.22] | 0.0001 |
7.2.5 Herbal medicine plus dexamethasone versus dexamethasone | |||
Liu et al. [38], 2015 | Yinchenlidan Decoction | MD-13.33 [− 17.34, − 9.32] | |
Zhao [41], 2011 | Qingyulidan Decoction | MD-10.13 [− 13.93, − 6.33] | |
Zhang [54], 2008 | Self prescribed prescription | MD-19.10 [− 23.90, − 14.30] | |
Chen and Mo [55], 2005 | Self prescribed prescription | MD-20.03 [− 27.91, − 12.15] | |
Subtotal (REM, I2 = 72%) | MD-15.05 [− 19.59, − 10.51] | < 0.0001 | |
8. The serum AST values | |||
8.1 Herbal medicine vs. Conventional medicine | |||
Li et al. [14], 2015 | Yinchenhao Decoction vs UDCA and SAM | MD 11.20 [7.86,14.54] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | MD −12.90 [− 37.51, 11.71] | |
Overall (REM, I2 = 72%) | MD 2.36 [− 20.40, 25.12] | 0.84 | |
8.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
8.2.1 Herbal medicine plus SAMe versus SAMe | |||
Liu et al. [46], 2013 | Yinchendanshao Decoction | MD-3.07 [− 7.69, 1.55] | |
Zhang [52], 2015 | Yinchenhao Decoction | MD-17.60 [− 26.96, − 8.24] | |
Liu et al. [70], 2019 | Wuling pill | MD − 35.30 [− 38.82, − 31.78] | |
Wang et al. [71], 2015 | Yinchenhao Decoction | MD − 6.10 [− 9.83, − 2.37] | |
8.2.2 Herbal medicine plus UDCA versus UDCA | |||
Yin [53], 2015 | Bushenqingli Decoction | MD − 20.23 [− 25.21, − 15.25] | |
Ma [56], 2010 | Self prescribed prescription | MD − 6.60 [− 15.02, 1.82] | |
Shu [58], 2018 | Qianyinlidan Decoction | MD − 29.83 [− 32.37, − 27.29] | |
Wei [63], 2016 | Self prescribed prescription | MD 8.00 [2.00, 14.00] | |
Gu et al. [66], 2014 | Yinchenhao Decoction | MD −1.76 [− 4.51, 0.99] | |
8.2.3 Herbal medicine plus UDCA and SAMe versus UDCA and SAMe | |||
Wang et al. [36], 2016 | Danyu Decoction | MD −27.30 [− 51.21, − 3.39] | |
Li et al. [14], 2015 | Yinchenhao Decoction | MD −19.00 [− 22.74, − 15.26] | |
Su et al. [60], 2015 | Lidan Decoction | MD − 14.85 [− 21.51, − 8.19] | |
Zheng [65], 2019 | Yinchen Decoction | MD − 18.79 [− 20.85, − 16.73] | |
Mao and He [67], 2014 | Qingganlidan Decoction | MD −11.20 [− 14.27, − 8.13] | |
8.2.4 Herbal medicine plus UDCA, SAMe and dexamethasone versusUDCA, SAMe and dexamethasone | |||
Shan et al. [50], 2016 | Huashilidan Decoction | MD-2.19 [− 6.05, 1.67] | 0.27 |
8.2.5 Herbal medicine plus dexamethasone versus dexamethasone | |||
Liu et al. [38], 2015 | Yinchenlidan Decoction | MD-17.48 [−24.21, − 10.75] | |
Zhao [41], 2011 | Qingyulidan Decoction | MD-4.65 [− 8.58, − 0.72] | |
Chen and Mo [55], 2005 | Self prescribed prescription | MD-6.54 [− 12.97, − 0.11] | |
9. The average gestational age of the newborn | |||
9.1 Herbal medicine vs. Conventional medicine | |||
Zhang [31], 2006 | Self prescribed prescription vs. SAMe and Reduced glutathione | MD 1.80 [1.04,2.56] | |
Li et al. [14], 2015 | Yinchenhao Decoction vs. UDCA and SAMe | MD − 0.50 [− 1.31,0.31] | |
Huang and Liu [34], 2004 | Yinchenhao Decoction vs SAMe | MD 0.70 [− 0.35, 1.75] | |
9.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Li et al. [14], 2015 | Yinchenhao Decoctionplus UDCA plus SAMe versus UDCA plus SAMe | MD 0.40 [− 0.37, 1.17] | |
Gu et al. [66], 2014 | Yinchenhao Decoction plus UDCA and SAMe versus UDCA and SAMe | MD 0.46 [− 0.29, 1.21] | |
Zhu and Huang [69], 2008 | Yinchenhao Decoction plus UDCA versus UDCA | MD 0.70 [− 0.35, 1.75] | |
Overall (FEM, I2 = 0%) | MD 0.49 [0.01, 0.97] | 0.05 | |
10. The number of premature birth | |||
10.1 Herbal medicine vs. Conventional medicine | |||
Yang [32], 2015 | Yinzhihuang oral liquid vs UDCA | RR 0.33 [0.04, 3.03] | |
Zhang et al. [35], 2006 | Jiaweiyinchen Decoction vs DXM | RR 0.23 [0.03, 1.97] | |
Overall (FEM, I2 = 0%) | RR 0.28 [0.06, 1.27] | 0.10 | |
10.2 Herbal medicine plus Conventional medicine versus Conventional medicine | |||
Wang et al. [36], 2016 | Yinzhihuang oral liquid plus UDCA and SAMe versus UDCA and SAMe | RR 0.27 [0.08, 0.90] | |
Zhou et al. [37], 2017 | Yinchailishi Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.13 [0.02, 0.94] | |
Wang X et al. [39], 2016 | Danyu Decoction plus UDCA versus UDCA | RR 0.30 [0.09, 1.03] | |
Yu [40], 2017 | Yinzhijiangdansuan Decoction plus UDCA versus UDCA | RR 0.32 [0.04, 2.91] | |
Zhao [41], 2011 | Qingyulidan Decoctionplus DXM, SAMe and phenobarbital versus DXM, SAMe plus phenobarbital | RR 0.45 [0.15, 1.42] | |
Shen and Tao [43], 2009 | Tuihuangguyuan Decoction plus SAMe versus SAMe | RR 0.50 [0.18, 1.38] | |
Wen et al. [44], 2014 | Self prescribed prescription plus SAMe versus SAMe | RR 0.47 [0.22, 1.01] | |
Lu [45], 2013 | Yinchenzhuyedihuang Decoction plus UDCA versus UDCA | RR 0.26 [0.07, 0.99] | |
Tian et al. [47], 2016 | Kangdanyu Decoction plus Reduced glutathione, UDCA, SAMe and DXM versus Reduced glutathione, UDCA and SAMe | RR 1.50 [0.84, 2.68] | |
Ding et al. [48], 2010 | Qingganhuayu Decoction plus SAMe versus SAMe | RR 0.51 [0.32, 0.82] | |
Shan et al. [50], 2016 | Huashilidan Decoction plus UDCA, SAMe and dexamethasone versus UDCA, SAMe and dexamethasone | RR 0.33 [0.07, 1.57] | |
Lan et al. [51], 2016 | Yinchenhao Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.42 [0.16, 1.07] | |
Zhang [52], 2015 | Yinchenhao Decoction plus SAMe versus SAMe | RR 0.29 [0.10, 0.79] | |
Yin [53], 2015 | Bushenqingli Decoction plus UDCA versus UDCA | RR 0.25 [0.06, 1.08] | |
Ma [56], 2010 | Self prescribed prescription plus UDCA versus UDCA | RR 0.36 [0.13, 1.03] | |
Su et al. [60], 2015 | Lidan Decoction plus UDCA, SAMe and Magnesium isoglycyrrhizinate versus UDCA, SAMe and Magnesium isoglycyrrhizinate | RR 0.33 [0.04, 3.06] | |
Wang et al. [62], 2018 | Yinzhihuang granule plus UDCA, SAMe and DXM versus UDCA, SAMe and DXM | RR 0.18 [0.04, 0.75] | |
Wei [63], 2016 | Self prescribed prescription plus UDCA versus UDCA | RR 0.33 [0.07, 1.52] | |
Zhang [64], 2017 | Lidan Decoction plus UDCA versus UDCA | RR 0.29 [0.06, 1.32] | |
Zheng [65], 2019 | Yinchen Decoction plus UDCA, SAMe and Phenobarbital versus UDCA, SAMe and Phenobarbital | RR 0.20 [0.01, 4.04] | |
Mao and He [67], 2014 | Qingganlidan Decoction plus UDCA and SAMe versus UDCA and SAMe | RR 0.23 [0.07, 0.77] | |
Mao [68], 2016 | Yinchenhao Decoction plus UDCA versus UDCA | RR 0.49 [0.05, 5.15] | |
Liu et al. [70], 2019 | Wuling pill plus SAMe versus SAMe | RR 0.43 [0.12, 1.58] | |
Wang et al. [71], 2015 | Yinchenhao Decoction plus SAMe versus SAMe | RR 0.60 [0.17, 2.18] | |
Du and Li [72], 2014 | Yiguanjian Decoction plus UDCA and DXM versus UDCA and DXM | RR 0.31 [0.12, 0.82] | |
Overall (FEM, I2 = 7%) | RR 0.41 [0.34, 0.51] | < 0.00001 | |