Study ID | Sample size (T/C) | Age (yrs, MD ± SD) | Gestational age of onset (wks, MD ± SD) | Gestational times | Intervention | Control | Course of treatment | Outcome |
---|---|---|---|---|---|---|---|---|
Comparison 1. Chinese medicine vs. Conventional medicine | ||||||||
Zhang [31], 2006 | 48/50 | 26.7 | 28–38 | Primipara | Self prescribed prescription | SAMe+Reduced glutathione | 7d a course of treatment, a total of 2 courses | 4, 6, 11 |
Yang [32], 2015 | 30/30 | T:27.2 ± 4.0 C:27.4 ± 3.9 | Not reported | M/P:11/19 M/P:13/17 | Yinzhihuang oral liquid | UDCA | 21d | 2, 5, 9, 12 |
Li et al. [33], 2015 | 60/60 | T:30.5 C:28.8 | T:32.4 C:33.4 | T:1.44 C:1.54 | Yinchenhao Decoction | UDCA+SAMe | 30d for Chinese medicine,10 d for medicine | 2, 6, 9, 10, 11 |
Huang and Liu [34], 2004 | 35/25 | T:34.5 ± 1.9 C:35.1 ± 2.2 | T:34.5 ± 1.9 C:35.1 ± 2.2 | Primipara | Yinchenhao Decoction | SAMe | 21d | 1, 3, 4, 6, 9, 11 |
Zhang et al. [35], 2006 | 31/29 | 26.8 | 29–40 | Not reported | Jiaweiyinchen Decoction | DXM | 7d | 1, 3, 4, 6, 7, 9, 10, 12 |
Comparison 2. Chinese medicine + Conventional medicine vs. Conventional medicine | ||||||||
Wang et al. [36], 2016 | 40/40 | T:29 ± 4.1 C:29.5 ± 4.2 | Not reported | Not reported | Yinzhihuang oral liquid+C | UDCA+SAMe | 7d | 2, 4, 6, 9, 10, 12 |
Zhou et al. [37], 2017 | 30/30 | T:26.3 ± 2.4 C:27.6 ± 2.1 | Not reported | Not reported | Yinchailishi Decoction+C | UDCA+SAMe | 14d | 1, 2, 4, 5, 6, 12 |
Liu et al. [38], 2015 | 78/78 | T:26.5 ± 7.4 C:26.2 ± 7.6 | Not reported | T:1.4 ± 0.8 C:1.5 ± 0.7 | Yinchenlidan Decoction+C | SAMe+DXM | 14d | 1, 2, 4, 6, 9, 10 |
Wang X et al. [39], 2016 | 55/55 | T:25.1 ± 4.2 C:25.3 ± 3.8 | Not reported | Not reported | Danyu Decoction+C | UDCA | 14d | 2, 5, 6, 7, 9, 12 |
Yu [40], 2017 | 29/28 | T:30.4 ± 3.5 C:31.2 ± 3.6 | Not reported | Not reported | Yinzhijiangdansuan Decoction+C | UDCA(+DXM) | 7d a course of treatment, a total of 2 courses | 2, 4, 5, 6, 7, 12 |
Zhao [41], 2011 | 60/60 | 21–38 | 21–38 | Not reported | Qingyulidan Decoction+C | DXM + SAMe+phenobarbital | 7d | 1, 2, 4, 5, 6, 7, 9, 10, 12 |
Wang and Lai [42], 2011 | 35/35 | T:24.3 ± 4.5 C:25.3 ± 3.5 | T:37.0 ± 2.1 C:36.4 ± 2.6 | Not reported | Yinchenlidan Decoction+C | UDCA | 10d | 1, 9 |
Shen and Tao [43], 2009 | 30/30 | T:25.3 ± 5.3 C:25.8 ± 4.9 | T:37.3 ± 3.3 C:36.0 ± 3.6 | Not reported | Tuihuangguyuan Decoction+C | SAMe | 10d | 1, 4, 5, 6, 7, 9, 12 |
Wen et al. [44], 2014 | 60/60 | T:26.3 ± 2.4 C:26.8 ± 2.2 | T:33.2 ± 3.1 C:33.5 ± 3.4 | Not reported | Self prescribed prescription+C | SAMe | 14d | 1, 12 |
Lu [45], 2013 | 35/24 | T:26.3 ± 2.4 C:25.0 ± 2.9 | Not reported | Not reported | Yinchenzhuyedihuang Decoction+C | UDCA | 12d | 2, 4, 5, 6, 9, 12 |
Liu et al. [46], 2013 | 15/15 | 26.45013 | Not reported | Not reported | Yinchendanshao Decoction+C | SAMe | 10d | 1, 2, 9, 10 |
Tian et al. [47], 2016 | 39/39 | T:25.5 ± 6.2 C:25.7 ± 5.8 | Not reported | Not reported | Kangdanyu Decoction+C | Reduced glutathione+UDCA+SAMe+DXM | 14d | 4, 5, 6, 7, 12 |
Ding et al. [48], 2010 | 94/94 | T:26.0 ± 3.8 C:25.5 ± 2.8 | Not reported | Not reported | Qingganhuayu Decoction+C | SAMe | 14d | 1, 5, 6, 12 |
Zhang et al. [49], 2014 | 30/30 | T:25.3 ± 2.1 C:26.6 ± 3.0 | Not reported | 1.44 ± 0.62 1.65 ± 0.81 | Qingdanzhiyang Decoction+C | SAMe+phenobarbital+DXM | 14d | 4, 5 |
Shan et al. [50], 2016 | 48/48 | T:26.3 ± 4.7 C:24.9 ± 4.3 | Not reported | Not reported | Huashilidan Decoction+C | UDCA+SAMe+DXM | 20d | 2, 4, 5, 7, 9, 12 |
Li et al. [33], 2015 | 60/60 | T:28.40151 C:28.80151 | T:34.4 ± 4.4 C:33.4 ± 4.4 | T:1.44 ± 4. C:1.54 ± 4. | Yinchenhao Decoction+C | UDCA+SAMe | 30d for Chinese medicine,10 d for medicine | 2, 6, 9, 10, 11 |
Lan et al. [51], 2016 | 40/40 | Not reported | Not reported | Not reported | Yinchenhao Decoction+C | UDCA+SAMe | 7d a course of treatment, a total of 2 courses | 1, 2, 4, 5, 12 |
Zhang [52], 2015 | 40/40 | T:26.7 ± 2.1 C:27.0 ± 1.8 | Not reported | Not reported | Yinchenhao Decoction+C | SAMe | 7d a course of treatment, a total of 2 courses | 2, 5, 9, 10, 12 |
Yin [53], 2015 | 30/30 | T:26.2 ± 2.9 C:25.9 ± 3.0 | Not reported | Not reported | Bushenqingli Decoction+C | UDCA | 7d a course of treatment, a total of 2 courses | 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 |
Zhang [54], 2008 | 44/42 | 26.6 ± 2.8 | 28–36 | Not reported | Self prescribed prescription+C | DXM + phenobarbital | 10d | 2, 9 |
Chen and Mo [55], 2005 | 35/35 | T:28.5 ± 2.4 C:27.8 ± 2.6 | Not reported | Not reported | Self prescribed prescription+C | DXM + VK3 | 14d | 3, 6, 7, 8, 9, 10 |
Ma [56], 2010 | 35/35 | T:28.5 ± 2.4 C:27.8 ± 2.6 | Not reported | Not reported | Self prescribed prescription+C | UDCA | 14d | 5, 6, 10, 12 |
Zhang et al. [57], 2016 | 40/41 | T:31.4 ± 9.4 C:32.1 ± 10.9 | Not reported | M/P:9/31 M/P:8/33 | Self prescribed prescription+C | UDCA+SAMe+DXM | 15d | 2 |
Shu [58], 2018 | 48/45 | T:27.6 ± 3.4 C:27.9 ± 4.0 | Not reported | M/P: 11/37 M/P:10/35 | Qianyinlidan Decoction+C | UDCA | 7d | 2, 9, 10 |
Deng [59], 2015 | 30/30 | 29.5 | Not reported | Not reported | Yinzhihuang oral liquid+C | UDCA | 10d | 1, 9 |
Su et al. [60], 2015 | 37/37 | T:29.4 ± 5.1 C:28.9 ± 4.8 | T:33.5 ± 4.1 C:33.1 ± 4.0 | M/P: 8/29 M/P:7/30 | Lidan Decoction+C | UDCA+SAMe+ Magnesium isoglycyrrhizinate | 14d | 2, 3, 4, 7, 9, 10, 12 |
Wang [61], 2014 | 36/36 | Not reported | T:32–36 C:32–36 | Not reported | Kangyudan Decoction+C | UDCA | 14d | 3, 5, 6, 7, 12 |
Wang et al. [62], 2018 | 30/30 | T:28 ± 3.12 C:29 ± 4.0 | T:34 ± 1.3 C:35 ± 1.5 | T:1.57 ± 0.65 C:1.47 ± 0.56 | Yinzhihuang granule+C | UDCA+SAMe+DXM | 14d | 4, 12 |
Wei [63], 2016 | 30/30 | T:30.5 ± 5.2 C:28.5 ± 6.1 | T:31.5 ± 4.3 C:32.3 ± 3.6 | Not reported | Self prescribed prescription+C | UDCA | 14d | 2, 3, 4, 6, 9, 10, 12 |
Zhang [64], 2017 | 62/62 | T:29.7 ± 3.8 C:28.6 ± 4.5 | T:32–37 C:31–38 | Not reported | Yinzhihuang granule+C | UDCA | 7d a course of treatment, a total of 2 courses | 4, 6, 12 |
Zheng [65], 2019 | 42/42 | T:26.9 ± 3.2 C:27.6 ± 3.3 | T:33.6 ± 2.3 C:34.2 ± 2.3 | M/P:22/20 M/P:24/18 | Lidan Decoction+C | UDCA+SAMe +phenobarbital | 14d | 2, 4, 5, 7, 9, 10, 12 |
Gu et al. [66], 2014 | 47/36 | T:27.8 ± 6.2 C:28.2 ± 5.0 | T:31.5 ± 2.8 C:31.1 ± 3.1 | T:2.2 ± 1.9 C:2.1 ± 2.0 | Yinchen Decoction+C | UDCA | 20d | 1, 2, 9, 10, 11 |
Mao and He [67], 2014 | 59/59 | T:26.2 ± 1.5 C:25.9 ± 1.4 | T:34.8 ± 0.7 T:35.2 ± 0.8 | Not reported | Qingganlidan Decoction+C | UDCA+SAMe | 14-21d | 2, 4, 5, 6, 9, 10, 12 |
Mao [68], 2016 | 39/38 | T:28.3 ± 2.2 C:28.6 ± 1.9 | T:29.9 ± 1.8 C:29.6 ± 2.1 | Not reported | Yinchenhao Decoction+C | UDCA | 7d | 4, 7, 8, 12 |
Zhu and Huang [69], 2008 | 35/25 | T:25.1 ± 2.8 C:23.9 ± 2.3 | T:34.5 ± 1.9 C:35.1 ± 2.2 | Not reported | Yinchenhao Decoction+C | UDCA | 21d | 3, 4, 6, 9, 11 |
Liu et al. [70], 2019 | 60/60 | T:25.2 ± 2.1 C:25.4 ± 2.3 | T:28.9 ± 2.1 C:29.0 ± 2.2 | Not reported | Wuling pill+C | SAMe | 14d | 1, 4, 6, 7, 8, 9, 10, 12 |
Wang et al. [71], 2015 | 20/20 | T:27.5 ± 5.1 C:26.7 ± 4.1 | T:30.8 ± 1.7 C:31.1 ± 1.8 | Not reported | Yinchenhao Decoction+C | SAMe | 21d | 1, 2, 3, 4, 5, 9, 10, 12 |
Du and Li [72], 2014 | 26/26 | T:22–37 C:24–36 | T:27–37 C:27–38 | M/P: 3/23 M/P:4/22 | Yiguanjian Decoction+C | UDCA+DXM | 7d a course of treatment | 4, 6, 7, 12 |
Zhang [73], 2005 | 40/40 | T:25.5 ± 2.5 C:24.6 ± 3.1 | T:33.8 ± 2 C:34.0 ± 2.2 | Not reported | Dangguidihuang Decoction+C | SAMe | 7d a course of treatment, a total of 3 courses | 1, 2, 4, 6, 9 |