Task | Cognitive domains and mood status assessments |
---|---|
Primary Outcomes | |
 MMSE | Global Cognitive function |
 Digit Span | Attention, short term, and working memory |
 RAVLT | Verbal immediate memory |
 VR I & II | Non-verbal memory and visuospatial function |
 Digit symbol substitution | Psychomotor speed |
 POMS | Tension, depression, anger, vigor, esteem related affect, fatigue and confusion |
Secondary Outcomes | |
 Biomarkers | BDNF, Oxidative stress (LPO, MDA), Inflammatory markers (iNOS, COX2) |
 Biochemical blood profile | Lipid profile and blood glucose profile |
 fMRI | Brain activation at the dorsolateral prefrontal cortex |