Primary Outcomes
|
MMSE
|
Global Cognitive function
|
Digit Span
|
Attention, short term, and working memory
|
RAVLT
|
Verbal immediate memory
|
VR I & II
|
Non-verbal memory and visuospatial function
|
Digit symbol substitution
|
Psychomotor speed
|
POMS
|
Tension, depression, anger, vigor, esteem related affect, fatigue and confusion
|
Secondary Outcomes
|
Biomarkers
|
BDNF, Oxidative stress (LPO, MDA), Inflammatory markers (iNOS, COX2)
|
Biochemical blood profile
|
Lipid profile and blood glucose profile
|
fMRI
|
Brain activation at the dorsolateral prefrontal cortex
|