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Table 1 Primary and secondary outcomes

From: The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial

Task Cognitive domains and mood status assessments
Primary Outcomes
 MMSE Global Cognitive function
 Digit Span Attention, short term, and working memory
 RAVLT Verbal immediate memory
 VR I & II Non-verbal memory and visuospatial function
 Digit symbol substitution Psychomotor speed
 POMS Tension, depression, anger, vigor, esteem related affect, fatigue and confusion
Secondary Outcomes
 Biomarkers BDNF, Oxidative stress (LPO, MDA), Inflammatory markers (iNOS, COX2)
 Biochemical blood profile Lipid profile and blood glucose profile
 fMRI Brain activation at the dorsolateral prefrontal cortex
  1. MMSE mini-mental state examination, RAVLT rey auditory verbal learning test, VR visual reproduction, POMS profile of mood state, BDNF brain-derived neurotrophic factor, LPO lipid hydroperoxides, MDA malondialdehyde, iNOS inducible nitric oxide synthase, COX2 cyclooxygenase 2, fMRI functional magnetic resonance imaging
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