Cost-effectiveness analysis of combining traditional Chinese medicine in the treatment of hypertension: compound Apocynum tablets combined with Nifedipine sustained-release tablets vs Nifedipine sustained-release tablets alone

Table 2 Summary of inputs used in the base-case model

Items	Base Case	Range	Source
Baseline age	67.5	60 ~ 75	MF Ju [29]
Transition probability
Alive without stroke/MI → stroke
Nifedipine	0.460%	0.0041 ~ 0.0051 0.0009 ~ 0.0011	[29,30,31]
Compound Apocynum+ Nifedipine Levamlodipine	0.102%	0.0009 ~ 0.0011	[29,30,31]
Alive without stroke/MI → stroke
Nifedipine	0.199%	0.0018 ~ 0.0022	[29,30,31]
Compound Apocynum+ Nifedipine Levamlodipine	0.193%	0.0017 ~ 0.0021	[29,30,31]
Stroke →Stroke	41.7%(5 year)	0.3753 ~ 0.4587	[32]
Post-stroke →Death	25.6%(4 year)	0.2304 ~ 0.2816	[33]
Stroke →Death	13.03%(5 year)	0.1172 ~ 0.1433	[33]
MI → MI	12.50%	0.1125 ~ 0.1375	[34]
Post-MI → Death	6.10%	0.0549 ~ 0.0671	[35]
MI → Death	9.70%	0.0873 ~ 0.1067	[34]
Utility
Alive without stroke	0.98	0.882 ~ 1	[36]
Stroke	0.5	0.45 ~ 0.55	[37]
MI	0.70	0.63 ~ 0.77	[37]
Post-stroke	0.63	0.567 ~ 0.693	[37]
Post-MI	0.8	0.72 ~ 0.88	[37]
Cost (USD/per year)
Nifedipine drug costs	16.31	14.68 ~ 17.95	[38]
Compound Apocynum+Nifedipine drug costs ii	102.42	92.18 ~ 112.66	[38]
MI (in hospital)	2538.01	2284.26 ~ 2791.87	[39]
Stroke (in hospital)	1843.86	1659.56 ~ 2028.35	[39]
Post-stroke	1692.15	1522.93 ~ 1861.36	[40]
Post-MI	20,141.84	1837.66 ~ 2246.03	[40]

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