Fig. 1

Histological effects of normal saline [b, c, & d], PA flower ethanolic extract (150 mg/kg) [e, f, & g], PA flower ethanolic extract (300 mg/kg) [h, i, & j] and Metformin (150 mg/kg) [k, l, & m] treatments on pancreatic sections in streptozotocin induced diabetic rats in comparison with non-diabetic healthy pancreatic section [a]. These figures were showed a normal architecture of pancreatic acini & normal islet of Langerhans in non-diabetic control [a], while a reduction in β-cell number i.e., destruction of the islet of Langerhans (*) [b] with a necrosis in a pancreatic acini (arrows) [c], fatty changes in pancreatic acini (interstitial vaculation ➔ arrow) [d] in pancreas of normal saline treated diabetic rats. Moreover, there was a reduction in the size of pancreatic islets; atrophied islets of Langerhans (arrows) [e], with a slight hemorrhage in the islets of beta cells (red color) [f & g] in pancreas of PA (150 mg/kg) treated diabetic rats. A reduction in the size of islets; atrophied islet of Langerhans (arrow) [h], with a slight hemorrhage in the pancreatic acini (arrow) [i], and a recovering from necrosis in the pancreatic acini [j] of PA (300 mg/kg) treated diabetic rats, while a hemorrhage in a pancreatic acini congestion (red color) [k], with a reduction in number of beta cells, hemorrhage [l], and slight minimal necrotic cells (arrows) [m] in the pancreatic acini of Metformin (150 mg/kg) treated diabetic rats (H & E 400X; Scale bar = 50 μm)