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Table 5 Targets of THSWD against DR

From: Uncovering the protective mechanism of Taohong Siwu decoction against diabetic retinopathy via HIF-1 signaling pathway based on network analysis and experimental validation

UniProt ID

Gene Symbol

Gene Name

P20248

CCNA2

cyclin A2

P12821

ACE

angiotensin I converting enzyme

P09488

GSTM1

glutathione S-transferase mu 1

P08473

MME

membrane metalloendopeptidase

P09038

FGF2

fibroblast growth factor 2

Q07869

PPARA

peroxisome proliferator activated receptor alpha

P15692

VEGFA

vascular endothelial growth factor A

P04406

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

Q04760

GLO1

glyoxalase I

P37231

PPARG

peroxisome proliferator activated receptor gamma

P35354

PTGS2

prostaglandin-endoperoxide synthase 2

P01112

HRAS

HRas proto-oncogene, GTPase

P29475

NOS1

nitric oxide synthase 1

P08069

IGF1R

insulin like growth factor 1 receptor

P30556

AGTR1

angiotensin II receptor type 1

P05019

IGF1

insulin like growth factor 1

P27361

MAPK3

mitogen-activated protein kinase 3

P01375

TNF

tumor necrosis factor

P14780

MMP9

matrix metallopeptidase 9

P05091

ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

P05121

SERPINE1

serpin family E member 1

Q00796

SORD

sorbitol dehydrogenase

P22392

NME2

NME/NM23 nucleoside diphosphate kinase 2

P00403

MT-CO2

cytochrome c oxidase subunit II

Q16698

DECR1

2,4-dienoyl-CoA reductase 1, mitochondrial

P14550

AKR1A1

aldo-keto reductase family 1 member A1

P09601

HMOX1

heme oxygenase 1

P15121

AKR1B1

aldo-keto reductase family 1 member B

P29474

NOS3

nitric oxide synthase 3

Q16539

MAPK14

mitogen-activated protein kinase 14

O60218

AKR1B10

aldo-keto reductase family 1 member B10

P18031

PTPN1

protein tyrosine phosphatase, non-receptor type 1

P55017

SLC12A3

solute carrier family 12 member 3

P11226

MBL2

mannose binding lectin 2

P21912

SDHB

succinate dehydrogenase complex iron sulfur subunit B

P07339

CTSD

cathepsin D

P17405

SMPD1

sphingomyelin phosphodiesterase 1

P14210

HGF

hepatocyte growth factor

P16581

SELE

selectin E

P16109

SELP

selectin P

P09238

MMP10

matrix metallopeptidase 10

P08254

MMP3

matrix metallopeptidase 3

P12724

RNASE3

ribonuclease A family member 3

P08253

MMP2

matrix metallopeptidase 2

P35228

NOS2

nitric oxide synthase 2

P51606

RENBP

renin binding protein

O60909

B4GALT2

beta-1,4-galactosyltransferase 2

P21554

CNR1

cannabinoid receptor 1

P13945

ADRB3

adrenoceptor beta 3

P08100

RHO

rhodopsin

P01308

INS

insulin

O00206

TLR4

toll like receptor 4

Q08209

PPP3CA

protein phosphatase 3 catalytic subunit alpha

P30711

GSTT1

glutathione S-transferase theta 1

P19440

GGT1

gamma-glutamyltransferase 1

P35968

KDR

kinase insert domain receptor

P35916

FLT4

fms related tyrosine kinase 4

P17948

FLT1

fms related tyrosine kinase 1

P04049

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

P42898

MTHFR

methylenetetrahydrofolate reductase

P19838

NFKB1

nuclear factor kappa B subunit 1

P20132

SDS

serine dehydratase

P10745

RBP3

retinol binding protein 3

P52757

CHN2

chimerin 2

P17707

AMD1

adenosylmethionine decarboxylase 1

P04179

SOD2

superoxide dismutase 2, mitochondrial

Q09472

EP300

E1A binding protein p300