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Table 5 Targets of THSWD against DR

From: Uncovering the protective mechanism of Taohong Siwu decoction against diabetic retinopathy via HIF-1 signaling pathway based on network analysis and experimental validation

UniProt ID Gene Symbol Gene Name
P20248 CCNA2 cyclin A2
P12821 ACE angiotensin I converting enzyme
P09488 GSTM1 glutathione S-transferase mu 1
P08473 MME membrane metalloendopeptidase
P09038 FGF2 fibroblast growth factor 2
Q07869 PPARA peroxisome proliferator activated receptor alpha
P15692 VEGFA vascular endothelial growth factor A
P04406 GAPDH glyceraldehyde-3-phosphate dehydrogenase
Q04760 GLO1 glyoxalase I
P37231 PPARG peroxisome proliferator activated receptor gamma
P35354 PTGS2 prostaglandin-endoperoxide synthase 2
P01112 HRAS HRas proto-oncogene, GTPase
P29475 NOS1 nitric oxide synthase 1
P08069 IGF1R insulin like growth factor 1 receptor
P30556 AGTR1 angiotensin II receptor type 1
P05019 IGF1 insulin like growth factor 1
P27361 MAPK3 mitogen-activated protein kinase 3
P01375 TNF tumor necrosis factor
P14780 MMP9 matrix metallopeptidase 9
P05091 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
P05121 SERPINE1 serpin family E member 1
Q00796 SORD sorbitol dehydrogenase
P22392 NME2 NME/NM23 nucleoside diphosphate kinase 2
P00403 MT-CO2 cytochrome c oxidase subunit II
Q16698 DECR1 2,4-dienoyl-CoA reductase 1, mitochondrial
P14550 AKR1A1 aldo-keto reductase family 1 member A1
P09601 HMOX1 heme oxygenase 1
P15121 AKR1B1 aldo-keto reductase family 1 member B
P29474 NOS3 nitric oxide synthase 3
Q16539 MAPK14 mitogen-activated protein kinase 14
O60218 AKR1B10 aldo-keto reductase family 1 member B10
P18031 PTPN1 protein tyrosine phosphatase, non-receptor type 1
P55017 SLC12A3 solute carrier family 12 member 3
P11226 MBL2 mannose binding lectin 2
P21912 SDHB succinate dehydrogenase complex iron sulfur subunit B
P07339 CTSD cathepsin D
P17405 SMPD1 sphingomyelin phosphodiesterase 1
P14210 HGF hepatocyte growth factor
P16581 SELE selectin E
P16109 SELP selectin P
P09238 MMP10 matrix metallopeptidase 10
P08254 MMP3 matrix metallopeptidase 3
P12724 RNASE3 ribonuclease A family member 3
P08253 MMP2 matrix metallopeptidase 2
P35228 NOS2 nitric oxide synthase 2
P51606 RENBP renin binding protein
O60909 B4GALT2 beta-1,4-galactosyltransferase 2
P21554 CNR1 cannabinoid receptor 1
P13945 ADRB3 adrenoceptor beta 3
P08100 RHO rhodopsin
P01308 INS insulin
O00206 TLR4 toll like receptor 4
Q08209 PPP3CA protein phosphatase 3 catalytic subunit alpha
P30711 GSTT1 glutathione S-transferase theta 1
P19440 GGT1 gamma-glutamyltransferase 1
P35968 KDR kinase insert domain receptor
P35916 FLT4 fms related tyrosine kinase 4
P17948 FLT1 fms related tyrosine kinase 1
P04049 RAF1 Raf-1 proto-oncogene, serine/threonine kinase
P42898 MTHFR methylenetetrahydrofolate reductase
P19838 NFKB1 nuclear factor kappa B subunit 1
P20132 SDS serine dehydratase
P10745 RBP3 retinol binding protein 3
P52757 CHN2 chimerin 2
P17707 AMD1 adenosylmethionine decarboxylase 1
P04179 SOD2 superoxide dismutase 2, mitochondrial
Q09472 EP300 E1A binding protein p300