Fig. 5

The core HIF-1 signaling pathway in THSWD against DR. a The KEGG pathway of HIF-1 signaling pathway. The targets of THSWD against DR were labelled as red. b The “herb-ingredient-target” network of HIF-1 signaling pathway. The red square represents herbs in THSWD, the green triangle represents active ingredients of those herbs, and the orange circle represents targets of THSWD against DR. The size of each node represents the correlation degree with other nodes, and the larger the node is, the stronger the correlation is