Table 3 Parameter Estimates of PMS severity (total & subtotal) using GEE Model for study groups

Total score

Echium amoenum

2.2

(−0.4,5.5)

0. 3

Placebo

Ref.

Age(year)

0.09

(−3.4,0.5)

0.7

BMI(kg/m²)

−0.5

(−1.2,0.2)

0.2

2nd follow up visit

−3.8

(−5.8,-1.8)

< 0.001

1st follow up visit

−4.0

(−5.9,-2.0)

< 0.001

Baseline

Ref.

Echium amoenum^a2nd follow up visit

−11.6

(− 14.7,-8.5)

< 0.001

Echium amoenum^a1st follow up visit

−6.2

(−9.8,-2.7)

0.001

Placebo ^abaseline

Ref.

Total score of symptoms

Echium amoenum

2.1

(−0.3,4.6)

0.2

Placebo

Ref.

Age(year)

−0.02

(− 0.3,0.3)

0.9

BMI(kg/m²)

−0.3

(−0.8,0.2)

0.2

2nd follow up visit

−2.8

(−4.5,-1.1)

0.001

1st follow up visit

−2.9

(−4.5,-1.3)

< 0.001

Baseline

Ref.

Echium amoenum^a2nd follow up visit

−8.5

(−11.0,-6.1)

< 0.001

Echium amoenum^a1st follow up visit

−4.5

(−7.3,-1.8)

0.001

Placebo ^abaseline

Ref.

Total score of Interference with

Echium amoenum

0.6

(−1.1,2.2)

0.5

Placebo

Ref.

Age(year)

0.1

(−0.1,0.3)

0.3

BMI(kg/m²)

−0.2

(−0.5,0.1)

0.2

2nd follow up visit

−1.1

(−1.6,-0.5)

< 0.001

1st follow up visit

−1.2

(−1.8,-0.5)

< 0.001

Baseline

Ref.

Echium amoenum^a2nd follow up visit

−2.8

(−4.1,-1.6)

< 0.001

Echium amoenum^a1st follow up visit

−1.3

(−2.7,0.07)

0.08

Placebo ^abaseline

Ref.