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Table 1 Hematological parameters of SD rats orally administered with fermented Citrus Sunki peel extract for 90 days

From: In vivo and in vitro safety evaluation of fermented Citrus sunki peel extract: acute and 90-day repeated oral toxicity studies with genotoxicity assessment

  Dose of fermented Citrus sunki peel extract (mg/kg)
0 500 1000 2000
Male (n = 10/group)
 WBC (103/mm3) 9.4 ± 2.4 8.7 ± 3.8 8.4 ± 2.4 8.4 ± 1.0
 RBC (106/mm3) 8.1 ± 0.4 7.8 ± 0.4 8.2 ± 0.3 7.8 ± 0.5
 HGB (g/dl) 14.4 ± 0.7 13.9 ± 0.7 14.6 ± 0.6 14.1 ± 0.6
 HCT (%) 39.1 ± 2.0 37.6 ± 2.0 39.3 ± 1.9 35.3 ± 7.6
 PLT (103/mm3) 789.0 ± 84.8 768.8 ± 71.4 800.2 ± 83.3 724.8 ± 57.3
 MCV (fl) 48.3 ± 2.6 48.3 ± 1.5 47.8 ± 1.2 48.8 ± 2.5
 MCH (pg) 17.8 ± 0.8 17.9 ± 0.6 17.8 ± 0.4 18.1 ± 0.9
 MCHC (g/dl) 36.9 ± 0.7 37.1 ± 0.6 37.2 ± 0.9 37.0 ± 0.6
 Neutrophils (%) 11.1 ± 3.1 11.1 ± 3.4 15.0 ± 4.1* 12.0 ± 2.4
 Eosinophils (%) 0.30 ± 0.22 0.21 ± 0.17 0.2 ± 0.09 0.15 ± 0.11
 Basophils (%) 0.57 ± 0.14 0.50 ± 0.15 0.56 ± 0.18 0.54 ± 0.16
 Lymphocytes (%) 83.1 ± 3.7 83.2 ± 4.0 78.5 ± 4.5* 82.1 ± 3.3
 Monocytes (%) 3.7 ± 0.6 3.8 ± 0.7 4.5 ± 0.9 4.0 ± 1.0
 Reticulocytes (%) 2.7 ± 0.4 2.2 ± 0.2* 2.9 ± 0.6 2.4 ± 0.3
 PT (sec) 16.0 ± 0.7 15.7 ± 0.5 15.7 ± 0.7 15.7 ± 0.8
 aPTT (sec) 43.0 ± 7.6 44.1 ± 2.0 42.7 ± 2.6 44.0 ± 4.3
Female (n = 10/group)
 WBC (103/mm3) 7.1 ± 1.6 6.7 ± 1.7 8.0 ± 2.0 7.8 ± 3.1
 RBC (106/mm3) 7.2 ± 0.2 7.2 ± 0.4 7.1 ± 0.4 7.0 ± 0.3
 HGB (g/dl) 13.6 ± 0.5 13.3 ± 0.3 13.3 ± 0.7 13.3 ± 0.4
 HCT (%) 36.9 ± 1.1 36.2 ± 1.2 36.2 ± 2.2 36.1 ± 1.2
 PLT (103/mm3) 700.0 ± 93.5 705.2 ± 41.3 654.3 ± 58.8 710.8 ± 48.6
 MCV (fl) 51.5 ± 0.9 50.2 ± 1.9 50.9 ± 2.0 51.3 ± 2.4
 MCH (pg) 19.0 ± 0.7 18.5 ± 0.7 18.7 ± 0.6 18.9 ± 0.7
 MCHC (g/dl) 36.9 ± 1.0 36.9 ± 0.9 36.8 ± 1.0 36.8 ± 0.7
 Neutrophils (%) 7.7 ± 1.4 7.4 ± 1.5 7.4 ± 2.0 8.6 ± 2.9
 Eosinophils (%) 0.12 ± 0.09 0.22 ± 0.18 0.17 ± 0.12 0.22 ± 0.19
 Basophils (%) 0.41 ± 0.10 0.47 ± 0.15 0.44 ± 0.13 0.42 ± 0.08
 Lymphocytes (%) 87.2 ± 2.0 87.4 ± 2.0 87.4 ± 2.5 86.1 ± 3.7
 Monocytes (%) 3.3 ± 0.5 3.4 ± 0.5 3.5 ± 0.6 3.6 ± 0.6
 Reticulocytes (%) 2.0 ± 0.3 2.5 ± 0.5* 2.5 ± 0.4 2.2 ± 0.4
 PT (sec) 15.9 ± 0.8 16.3 ± 0.5 15.9 ± 0.6 15.9 ± 0.6
 aPTT (sec) 47.6 ± 5.9 49.5 ± 6.4 44.8 ± 8.0 41.6 ± 7.2
  1. WBC white blood cells, RBC red blood cells, Hb hemoglobin, HCT hematocrit, PLT platelet, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PT partial thromboplastin time and aPTT activated partial thromboplastin time
  2. *; p < 0.05 by one-way ANOVA followed by post-hoc Dunnet’s test